Research in the Kopeček/Yang Biomedical Polymers Laboratory in the Center for Controlled Chemical Delivery focuses on the design, synthesis, and characterization of biomedical materials and macromolecular therapeutics. We are studying tailor-made hybrid macromolecules which mimic structures developed by Mother Nature. The interdisciplinary research field involves synthetic and physical chemistry, molecular engineering, pharmaceutics, molecular biology, and immunology. The major projects are described below:
- Combination chemotherapy and immunotherapy of immunosuppressive cancers
- Macromolecular therapeutics for brain delivery and treatment of primary central nervous system lymphoma and traumatic brain injury
- Drug-free macromolecular therapeutics as a B-cell depletion strategy for various diseases
- Crosslinking-mediated endocytosis
- Antibody-drug conjugates