Patents

[33]Angiopep-2 Mediated Brain-Targeted Paclitaxel Conjugate for the Treatment of Alzheimer Disease. J. Yang, D. Cross, J. Kopeček, M.T. Gambles (2023). US Provisional Patent Application, filed July 21, 2023.
[32]Vector-Guided Brain Delivered Therapy for Multiple Sclerosis. J. Kopeček, M.T. Gambles, J. Yang (2023). US Provisional Patent Application, filed July 24, 2023.
[31]Multi-Specific Self-Assembled Drug-Free Macromolecular T-Cell Engagers. J. Kopeček, M.T. Gambles, J. Yang (2023). US Provisional Application, filed July 20, 2023.
[30]Bone Fracture Repair by Targeting of Agents that Promote Bone Healing. S.A. Low, P.S. Low, C. Galliford, J. Kopeček, J. Yang (2023) US 11,623,009 B2
[29]Compositions and methods for inducing apoptosis. J. Kopeček, J. Yang, T.-W. Chu, (2022) US 11,213,540 B2.
[28]Compositions and methods for inducing apoptosis. J. Kopeček, J. Yang, T.-W. Chu, (2022) US 11,213,540 B2. 
[27]Compositions and Methods for Using Albumin-Based Nanomedicines. J. Kopeček, J. Yang, (2021) US 10,925,973 B2.
[26]Bone Fracture Repair by Targeting of Bone Anabolic Agents. J. Kopeček, S. Low, J. Yang, P. Low, C. Galliford, (2020) US 10,744,203 B2.
[25]Macromolecular Delivery Systems for Non-invasive Imaging, Evaluation, and Treatment of Arthritis and Other Inflammatory Diseases. D. Wang, J. Kopeček, S.C. Miller, P. Kopečková (2019) US 10,172,962 B2.
[24]Compositions and methods for inducing apoptosis. J. Kopeček, J. Yang, T.-W. Chu. (2019) US 10,251,906 B2.
[23]Antibody-Polymer-Drug Conjugates. J. Yang, J. Kopeček, L. Zhang, J. Fang, PCT Application Serial Number PCT/US17/56515 (filed October 2017).
[22]HPMA-Drug Conjugates for the Treatment of Acute Myeloid Leukemia. P. Shami, J. Kopeček, J. Yang, R. Zhang. PCT Application No. PCT/US2016/043732 (filed July 2016).
[21]Compositions and methods for inducing apoptosis. J. Kopeček, J. Yang, T.-W. Chu. (2019) US 10,251,906 B2.
[20]Polymeric drug delivery conjugates and methods of making and using thereof. H. Pan, J. Yang, P. Kopečková, K. Luo, J. Kopeček (2016) US 9,289,510.
[19]Conjugate of a polymer, an anti-angiogenesis agent and a targeting moiety, and uses thereof in the treatment of bone related angiogenesis conditions. R. Satchi-Fainaro, E. Segal, J. Kopeček, P. Kopečková, and H. Pan. (2014), US 8,703,114.
[18]Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof. Z-R. Lu, J. Kopeček, and D.L. Parker. (2010), US 7,745,590.
[17]Hydrogels of water soluble polymers crosslinked by protein domains. J. Kopeček, R. Stewart, K. Caldwell, C. Wang, and C-H. Ho. (2007), US 7,179,487.
[16]Degradable macromolecular magnetic resonance imiging contrast agents and methods thereof. Z-R. Lu, J. Kopeček, and D.L. Parker. (2006), US 6,982,324.
[15]Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting pH-dependent swelling. J. Kopeček, S.W. Kim, H. Brondsted, and P. Kopečková. (1995), US 5,415,864.
[14]Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light. J. Kopeček and N.L. Krinick. (1993), US 5,258,453.
[13]Polymer supersurfactants for protein resistance and protein removal. J.D. Andrade, J. Kopeček, and J.H. Lee. (1991), US 5,075,400.
[12]Synthetic polymeric drugs. J. Kopeček, P. Rejmanová, J. Strohalm, K. Ulbrich, B. Říhová, V. Chytrý, J.B. Lloyd, R. Duncan. (1991), US 5,037,883.
[11]Preparation of biogically active substances bearing -NH2 groups in a form releasable by enzymatic cleavage. J. Drobník, J. Kopeček, J. Labský, P. Rejmanová, J. Exner, J. Kálal. (1978), US 4,097,470.
[10]Hydrophilic N,N-diethyl acrylamide copolymers. D. Lím, J. Kopeček, H. Bažilová née Zvěřinová, J. Vacík. (1978), US 4,074,039.
[9]Copolymers based on N-substituted acrylamides, N-substituted methacrylamides and N,N-disubstituted acrylamides and the method of their manufacturing. J. Kopeček, K. Ulbrich, J. Vacík, J. Strohalm, V. Chytrý, J. Drobník, J. Kálal. (1977), US 4,062,831.
[8]Soluble hydrophilic polymers and process for processing the same. J. Kopeček, J. Vacík, L. Šprincl. (1976), US 3,997,660.
[7]Infusion solutions and method of manufacturing same. D. Lím, L. Šprincl, J. Kopeček, J. Vacík. (1976), US 3,954,966.
[6]Hydrophilic nitrite copolymers. J. Vacík and J. Kopeček. (1976), US 3,931,123.
[5]Soluble hydrophilic polymers and process for processing the same. J. Kopeček, J. Vacík, L. Šprincl(1976), US 3,931,111.
[4]Method for producing of articles from hydrophilic polymers appropriate for repeated or long-term contact with living tissue or mucous membrane. D. Lím, J. Kopeček, H. Bažilová, J. Vacík. (1975), US 3,876,594.
[3]Device for connecting or joining the ends of interrupted tubular organs in surgical operations without stitching. D. Lím, L. Šprincl, J. Kopeček. US 3,774,615
[2]Method of hydrophilization of transparent objects made of hydrophobic organic polymers. D. Lim, J. Kopeček, and J. Vacík. (1973), US 3,745,042.
[1]Increasing permeability of reverse osmosis membranes. J. Kopeček and S. Sourirajan. (1970), US 3,536,612.