Publications

[464]Multiantigen T-Cell Hybridizers: A Two-Component T-Cell-Activating Therapy. M.T. Gambles, S. Li, I. Kendell, J. Li, D. Sborov, P. Shami, J. Yang, J. Kopeček. ACS Nano (2024) [doi]
[463]Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics Induce Apoptosis in Chronic Lymphocytic Leukemia Patient Cells by Crosslinking of CD20 and/or CD38 Receptors. J. Li, M.T. Gambles, B. Jones, J.A. Williams, N.J. Camp, P.J. Shami, J. Yang, J. Kopeček. Drug Delivery Translational Res. (2024); [doi].
[462]Hydrophilic Biomaterials: From Crosslinked and Self-Assembled Hydrogels to Polymer-Drug Conjugates and Drug-Free Macromolecular Therapeutics. J. Kopeček.
Invited “Magnum Opus” manuscript. J. Controlled Release 373, 1-22 (2024); [doi].
[461]Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. M.T. Gambles, D. Sborov, P. Shami, J. Yang, J. Kopeček. Macromol. Biosci. (2023) 2300375; [doi].
[460]Multi-Targeted Immunotherapeutics to Treat B Cell Malignancies. M.T. Gambles, J. Yang, J. Kopeček, J. Controlled Release 358, 232-258 (2023) [doi].
[459]Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model. Z.-H. Peng, C.M. Jogdeo, J. Li, Y. Xie, Y. Wang, Y.M. Sheinin, J. Kopeček, D. Oupický, Pharmaceutics 14, 1725 (2022) [doi].
[458]Crosslinking of CD20 and CD38 by Drug-Free Macromolecular Therapeutics Enhances B Cell Apoptosis. M.T. Gambles, J. Li, D.C. Radford, D. Sborov, P. Shami, J. Yang, J. Kopeček, Simultaneous Crosslinking of CD20 and CD38 Receptors by Drug-Free Macromolecular Therapeutics Enhances B Cell Apoptosis In Vitro and In Vivo. J. Controlled Release 350, 584-599 (2022) [doi]. 
[457]Nanomedicines in B Cell-Targeting Therapies. J. Wang, J. Yang, J. Kopeček, Acta Biomater. 137, 1-19 (2022) [doi]. 
[456]Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells. M.T. Gambles, J. Li, J. Wang, D. Sborov, J. Yang, J. Kopeček, Molecules 26, 4658 (2021) [doi]. 
[455]Combination Treatment with Immunogenic and Anti-PD-L1 Polymer-Drug Conjugates of Advanced Tumors in a Transgenic MMTV-PyMT Mouse Model of Breast Cancer. L. Li, J. Wang, D.C. Radford, J. Kopeček, J. Yang, J. Controlled Release. 329 (2021): 1129-1138. [doi]
[454]Dendronized polymer conjugates with amplified immunogenic cell death for oncolytic immunotherapy. Y. Li, L. Li, J. Wang, D.C. Radford, Z. Gu, J. Kopeček, J. Yang. J. Controlled Release. 329 (2020): 1129-1138
[453]Polymer Nanomedicines. J. Kopeček, J. Yang. Adv. Drug Deliv. Rev.. 156 (2020): 40-66. [doi]
[452]Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model. J. Wang, Y. Li, L. Li, J. Yang, J. Kopeček. Macromol. Biosci.. 20 (2020): 1900445. [doi]
[451]Multivalent HER2-Binding Polymer Conjugates Facilitate Rapid Endocytosis and Enhance Intracellular Drug Delivery. D.C. Radford, J. Yang, M. Doan, L. Li, A.S. Dixon, S.C. Owen, J. Kopeček. J. Controlled Release. 319 (2020): 285-299. [doi]
[450]Inhibition of Immunosuppresive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking. L. Li, Y. Li, C.-H. Yang, D.C. Radford, J. Wang, M. Janát-Amsbury, J. Kopeček, J. Yang. Adv. Funct. Mater.. 30 (2020): 1908961. [doi]
[449]Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface. L. Li, J. Wang, Y. Li, D.C. Radford, J. Yang, J. Kopeček. ACS Nano. 13 (2019): 11422-11432. ACS Editors’s Choice [doi]
[448]Drug-free Macromolecular Therapeutics Induce Apoptosis in Cells Isolated from Patients with B Cell Malignancies with Enhanced Apoptosis Induction by Pretreatment with Gemcitabine. J. Wang, L. Li, J. Yang, P.M. Clair, M. Glenn, D.M. Stephens, D.C. Radford, K.M. Kosak, M.W. Deininger, P.J. Shami, J. Kopeček. Nanomedicine. NBM 16 (2019): 217-225. [doi]
[447]Biorecognition: A Key to Drug-free Macromolecular Therapeutics. J. Yang, L. Li, J. Kopeček. Biomaterials. 190-191 (2019): 11-23. [doi]
[446]Drug-Free Albumin-Triggered Sensitization of Cancer Cells to Anticancer Drugs. L. Li, J. Yang, S. Soodvilai, J. Wang, P. Opanasopit, J. Kopeček. J. Controlled Release. 293 (2019): 84-93. [doi]
[445]Drug-Free Macromolecular Therapeutics Exhibit Amplified Apoptosis in G2/M Phase Arrested Cells. L. Li, J. Yang, J. Wang, J. Kopeček. J. Drug Targeting. 27 (2018): 566-572 [doi]
[444]Amplification of CD20 Crosslinking in Rituximab Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics. L. Li, J. Yang, J. Wang, J. Kopeček. ACS Nano. 12 (2018): 3658-3670. [doi]
[443]Human Serum Albumin Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface. L. Zhang, Y. Fang, L. Li, J. Yang, D.C. Radford, J. Kopeček. Macromol. Biosci. 18 (2018): 1800224; [doi]
[442]Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway. L. Li, J. Yang, J. Wang, J. Kopeček. Macromol. Biosci. 18 (2018): 1700196; [doi]
Highlighted in Advanced Science News
[441]The Light at the End of the Tunnel – Second Generation HPMA Conjugates for Cancer Treatment. J. Yang, J. Kopeček. Curr. Opin. Colloid Interface Sci. 31 (2017): 30-42. [doi]
[440]A New Construct of Antibody-Drug Conjugates for Treatment of Non-Hodgkin’s Lymphoma. L. Zhang, Y. Fang, J. Kopeček, J. Yang. Eur. J. Pharm. Sci. 103 (2017): 36-46. [doi]
[439]Drug-Free Macromolecular Therapeutics: Impact of Structure on Induction of Apoptosis in Raji B Cells. L. Zhang, Y. Fang, J. Yang, J. Kopeček. J. Controlled Release 263 (2017): 139-150. [doi]
[438]Backbone Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts. J. Yang, R. Zhang, H. Pan, Y. Li, Y. Fang, L. Zhang, J. Kopeček. Mol. Pharmaceutics. 14 (2017): 1384-1394. [doi]
[437]Healing Efficacy of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Repair. S.A. Low, C.V. Galliford, Y.L. Jones-Hall, J. Roy, J. Yang, P.S. Low, J. Kopeček. Nanomedicine (Lond.). 12 (2017): 185-193. [doi]
[436]Diverse Applications of Nanomedicine. B. Pelaz, C. Alexiou, R. Alvarez-Puebla, F. Alves, A. Andrews, S. Ashraf, L. Balogh, L. Ballerini, A. Bestetti, C. Brendel, S. Bossi, M. Carril, W. Chan, C. Chen, X. Chen, S. Shen, Z. Cheng, D. Cui, J. Du, C. Dullin, A. Escudero, N. Feliu, M. Gao, M. George, A. Grünweller, Z. Gu, Y. Gogotsi, N. Halas, N. Hampp, R. Hartmann, M. Hersam, P. Hunziker, J. Ji, X. Jiang, P. Jungebluth, P. Kadhiresan, K. Kataoka, A. Khademhosseini, J. Kopeček, N. Kotov, H. Krug, D.S. Lee, C.-M. Lehr, K.W. Leong, X.-J. Liang, M.L. Ling, L. Liz-Marzán, X. Ma, P. Macchiarini, H. Meng, H. Möhwald, P. Mulvaney, A. Nél, S. Nie, P. Nordlander, T. Okano, J. Oliviera, T.H. Park, R. Penner, M. Prato, V. Puntes, V. Rotello, A. Samarakoon, R. Schaak, Y. Shen, S. Sjoqvist, A.G. Skirtach, M. Sollman, M. Stevens, B.Z. Tang, R. Tietze, B. Udugama, H.-W. Sung, T. Weil, P. Weiss, I. Willner, Y. Wu, L. Yang, Z. Yue, Q. Zhang, Q. Zhang, X. Zhang, Y. Zhao, X. Zhou, W. Parak. ACS Nano. 11 (2017): 2313-2381. [doi]
[435]FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate. R. Zhang, J. Yang, D.C. Radford, Y. Fang, J. Kopeček. Macromol. Biosci. 17, (2016):1600125. [doi]
[434]Indium-based and Iodine-based Labeling of HPMA Copolymer-Epirubicin Conjugates: Impact of Structure on the In Vivo Fate. L. Zhang, R. Zhang, J. Yang, J. Wang, J. Kopeček, J. Controlled Release. 235 (2016): 306-318. [doi]
[433]Tracking and quantifying polymer therapeutic distribution on a cellular level using 3D dSTORM. J.M. Hartley, R. Zhang, M. Gudheti, J. Yang, J. Kopeček. J. Controlled Release. 231 (2016): 50-59. [doi]
[432]Design of Smart HPMA Copolymer-Based Nanomedicines. Yang, J. Kopeček, J. Controlled Release 240 (2016): 9-23. [doi]
[431]N-(2-Hydroxypropyl)methacrylamide Copolymer–Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia. R Zhang, J Yang, Y Zhou, P J Shami, J Kopeček. Macromol Biosci. 16 (2016): 121-128. [doi]
[430]Smart Polymer-Based Nanomedicines. J M Hartley, J Kopeček. Smart Pharmaceutical Nanocarriers. Ed. V P Torchilin (2016): 373-413.
[429]Hybrid Polymeric Hydrogels via Peptide Nucleic Acid (PNA)/DNA Complexation. T-W Chu, J Feng, J Yang, J Kopeček. J. Controlled Release. 220 (2015): 608-615. [doi]
[428]Biodistribution of Facture-Targeted GSK3β-loaded Micelles for Improved Fracture Healing. SA Low, CV Galiford, J Yang, PS Low, J. Kopeček.Biomacromolecules. 16 (2015): 3145-3153. [doi]
[427]FRET-Trackable Biodegradable HPMA Copolymer-Epirubicin Conjugates for Ovarian Carcinoma Therapy. J Yang, R Zhang DC Radford, J Kopeček. J. Controlled Release. 218 (2015): 36-44. [doi]
[426]Polymeric biomaterials and nanomedicines. J Yang, J Kopeček. J. Drug Deliv. Sci. Technol. 30 (2015): 318-330. [doi]
[425]Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates. J M Hartley, T-W Chu, E M Peterson, R Zhang, J Yang, J Harris, J Kopeček. ChemBioChem. 16 (2015): 1725-1729. [doi]
[424]Enhancing Accumulation and Penetration of HPMA Copolymer–Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer. Z-H Peng, J Kopeček. J. Am. Chem. Soc.. 137 (2015): 6726-6729. [doi]
[423]Drug-free macromolecular therapeutics – a new paradigm in polymeric nanomedicines. T-W Chu, J Kopeček. Biomaterials Sci. 3 (2015): 908-922. [doi]
[422]Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a “Drug-Free” Therapeutic System. R Zhang, J Yang, T-W Chu, J M Hartley, J Kopeček. Adv Healthc Mater. 4 (2015): 1054-1065. [doi]
[421]A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. T-W Chu, R Zhang, J Yang, M P Chao, P J Shami, J Kopeček. Theranostics. 5 (2015): 834-846. [doi]
[420]Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics. J Yang, J Kopeček. Bioinspired Systems for Drug and Gene Delivery. Ed. Z-W Gu (2015): 1-27.
[419]HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells. Z-H Peng, J Kopeček. ACS Macro Lett. 3 (2014): 1240-1243. [doi]
[418]Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel. Y Zhou, J Yang, R Zhang, J Kopeček. Eur J Pharm Biopharm. 89 (2014): 107-115. [doi]
[417]Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells. T-W Chu, K M Kosak, P J Shami, J Kopeček. Drug Deliv Transl Res. 4 (2014): 389-394. [doi]
[416]Bone-Targeted Acid-Sensitive Doxorubicin Conjugate Micelles as Potential Osteosarcoma Therapeutics. S A Low, J Yang, J Kopeček. Bioconjugate Chem.. 25 (2014): 2012-2020. [doi]
[415]Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates. R Zhang, J Yang, M Sima, Y Zhou, J Kopeček. Proc. Natl. Acad. Sci. U.S.A.. 111 (2014): 12181-12186. [doi]
[414]Immunogenicity of coiled-coil based drug-free macromolecular therapeutics. Miloslav Kverka, J M Hartley, T-W Chu, J Yang, R Heidchen, J Kopeček. Biomaterials. 35 (2014): 5886-5896. [doi]
[413]Macromolecular therapeutics. J Yang, J Kopeček. J Control Release. 190 (2014): 288-303. [doi]
[412]Polymeric Drugs. J Yang, J Kopeček. Encyclopedia of Polymeric Nanomaterials. Springer Berlin Heidelberg (2014): 1-9.
[411]Synthesis and activity of tumor-homing peptide iRGD and histone deacetylase inhibitor valproic acid conjugate. Z-H Peng, J Kopeček. Bioorg. Med. Chem. Lett.. 24 (2014): 1928-1933. [doi]
[410]Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis. T-W Chu, J Yang, R Zhang, M Sima, J Kopeček. ACS Nano. 8 (2014): 719-730. [doi]
[409]Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells. A Duangjai, K Luo, Y Zhou, J Yang, J Kopeček. Eur J Pharm Biopharm. 87 (2014): 187-196. [doi]
[408]HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects. Y Zhou, J Yang, J S Rhim, J Kopeček. J Control Release. 172 (2013): 946-953. [doi]
[407]Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. Z-H Peng, M Sima, Mohamed E Salama, P Kopečková, J Kopeček. J Drug Target. 21 (2013): 968-980. [doi]
[406]Efficiency of high molecular weight backbone degradable HPMA copolymer-Prostaglandin E-1 conjugate in promotion of bone formation in ovariectomized rats. H Pan, M Sima, S C Miller, P Kopečková, J Yang, J Kopeček. Biomaterials. 34 (2013): 6528-6538. [doi]
[405]Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment. N Larson, J Yang, A Ray, D L Cheney, H Ghandehari, J Kopeček. Int J Pharm. 454 (2013): 435-443. [doi]
[404]Cancer Stem Cells: Potential Target For Anti-Cancer Nanomedicines. Y Zhou, J Yang, J Kopeček. Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications. Eds. C Scholz, J Kressler. (2013): 127-149.
[403]Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. R Zhang, K Luo, J Yang, M Sima, Y Sun, M M Janát-Amsbury, J Kopeček. J Control Release. 166 (2013): 66-74. [doi]
[402]Synthesis of Long-Circulating, Backbone Degradable HPMA CopolymerDoxorubicin Conjugates and Evaluation of Molecular-Weight-Dependent Antitumor Efficacy. H Pan, M Sima, J Yang, J Kopeček. Macromol Biosci. 13 (2013): 155-160. [doi]
[401]Polymer–drug conjugates: Origins, progress to date and future directions. J Kopeček. Adv. Drug. Deliv. Rev.. 65 (2013): 49-59. [doi]
[400]Biological rationale for the design of polymeric anti-cancer nanomedicines. Y Zhou, J Kopeček. J Drug Target. 21 (2013): 1-26. [doi]
[399]Anti-CD20 multivalent HPMA copolymer-Fab’ conjugates for the direct induction of apoptosis. T-W Chu, J Yang, J Kopeček. Biomaterials. 33 (2012): 7174-7181. [doi]
[398]Smart Self-Assembled Hybrid Hydrogel Biomaterials. J Kopeček, J Yang. Angewandte Chemie International Edition. 51 (2012): 7396-7417. [doi]
[397]Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-Overexpressing Ovarian Carcinoma. G Journo-Gershfeld, D Kapp, Y Shamay, J Kopeček, A David. Pharm. Res.. 29 (2012): 1121-1133. [doi]
[396]Biological Activity of Anti-CD20 Multivalent HPMA Copolymer-Fab’ Conjugates. R N Johnson, P Kopečková, J Kopeček. Biomacromolecules. 13 (2012): 727-735. [doi]
[395]Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Y Zhou, J Yang, J Kopeček. Biomaterials. 33 (2012): 1863-1872. [doi]
[394]Targeting polymer therapeutics to bone. S A Low, J Kopeček. Adv. Drug. Deliv. Rev.. 64 (2012): 1189-1204. [doi]
[393]Targeting of Multidrug-Resistant Human Ovarian Carcinoma Cells With Anti-P-Glycoprotein Antibody Conjugates. K D Fowers, J Kopeček. Macromol Biosci. 12 (2012): 502-514. [doi]
[392]Prostate-Cancer-Targeted N-(2-Hydroxypropyl)methacrylamide Copolymer/Docetaxel Conjugates. J Liu, P Kopečková, H Pan, M Sima, P Buehler, P Wolf, U Elsaesser-Beile, J Kopeček. Macromol Biosci. 12 (2012): 412-422. [doi]
[391]Coiled-coil based drug-free macromolecular therapeutics: In vivo efficacy. K Wu, J Yang, J Liu, J Kopeček. J Control Release. 157 (2012): 126-131. [doi]
[390]Design of Polymer-Drug Conjugates. J Kopeček, P Kopečková. Drug Delivery in Oncology. Eds. F Kratz, P D Senter, H Steinhagen. Drug Delivery in Oncology: From Basic Research to Cancer Therapy, Vols 1-3 (2012): 485-512.
[389]Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances. E Segal, H Pan, L Benayoun, P Kopečková, Y Shaked, J Kopeček, R Satchi-Fainaro. Biomaterials. 32 (2011): 4450-4463. [doi]
[388]Synthesis and Characterization of Poly(ε-caprolactone)-block-poly[N-(2-hydroxypropyl)methacrylamide] Micelles for Drug Delivery. S G Krimmer, H Pan, J Liu, J Yang, J Kopeček. Macromol Biosci. 11 (2011): 1041-1051. [doi]
[387]Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition\textbackslashtextminusFragmentation Chain Transfer Polymerization and Click Chemistry. K Luo, J Yang, P Kopečková, J Kopeček. Macromolecules. 44 (2011): 2481-2488. [doi]
[386]Backbone Degradable Multiblock N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates via Reversible Addition\textbackslashtextminusFragmentation Chain Transfer Polymerization and Thiol\textbackslashtextminusene Coupling Reaction. H Pan, J Yang, P Kopečková, J Kopeček. Biomacromolecules. 12 (2011): 247-252. [doi]
[385]Synthesis of biodegradable multiblock copolymers by click coupling of RAFT-generated heterotelechelic polyHPMA conjugates. J Yang, K Luo, H Pan, P Kopečková, J Kopeček. React Funct Polym. 71 (2011): 294-302. [doi]
[384]Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress. K Giantsos-Adams, V Lopez-Quintero, P Kopečková, J Kopeček, John M Tarbell, R Dull. Biomaterials. 32 (2011): 288-294. [doi]
[383]Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds. L C Wu, J Yang, J Kopeček. Biomaterials. 32 (2011): 5341-5353. [doi]
[382]Biomaterials and Drug Delivery: Past, Present, and Future. J Kopeček. Mol. Pharm. 7 (2010): 922-925. [doi]
[381]Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics. J Liu, H Bauer, J Callahan, P Kopečková, H Pan, J Kopeček. J Control Release. 143 (2010): 71-79. [doi]
[380]HPMA copolymers: Origins, early developments, present, and future. J Kopeček, P Kopečková. Adv. Drug. Deliv. Rev.. 62 (2010): 122-149. [doi]
[379]Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil-Mediated Cross-Linking of Antigens on the Cell Surface. K Wu, J Liu, R N Johnson, J Yang, J Kopeček. Angew. Chem. Int. Ed.. 122 (2010): 1493-1497. [doi]
[378]Synthesis and Characterization of Enzymatically Degradable PEG-Based Peptide-Containing Hydrogels. J Yang, M T Jacobsen, H Pan, J Kopeček. Macromol Biosci. 10 (2010): 445-454. [doi]
[377]Hydrogels: From soft contact lenses and implants to self-assembled nanomaterials. J Kopeček. J Polym Sci A Polym Chem. 47 (2009): 5929-5946. [doi]
[376]Self-Assembled Hydrogels from Poly[N-(2-hydroxypropyl)methacrylamide] Grafted with β-Sheet Peptides. L C Radu-Wu, J Yang, K Wu, J Kopeček. Biomacromolecules. 10 (2009): 2319-2327. [doi]
[375]Stimuli-Responsive Properties of Peptide-Based Copolymers Studied via Directional Growth of Self-Assembled Patterns on Solid Substrate. R Sheparovych, Y Roiter, J Yang, J Kopeček, S Minko. Biomacromolecules. 10 (2009): 1955-1961. [doi]
[374]Biorecognition and Subcellular Trafficking of HPMA Copolymer-Anti-PSMA Antibody Conjugates by Prostate Cancer Cells. J Liu, P Kopečková, P Buehler, P Wolf, H Pan, H Bauer, U Elsaesser-Beile, J Kopeček. Mol. Pharm. 6 (2009): 959-970. [doi]
[373]Intracellular Trafficking and Subcellular Distribution of a Large Array of HPMA Copolymers. J Callahan, P Kopečková, J Kopeček. Biomacromolecules. 10 (2009): 1704-1714. [doi]
[372]Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. S-Q Gao, Y Sun, P Kopečková, C M Peterson, J Kopeček. Macromol Biosci. 9 (2009): 1135-1142. [doi]
[371]Targeting Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics. E Segal, H Pan, P Ofek, T Udagawa, P Kopečková, J Kopeček, R Satchi-Fainaro. PLoS ONE. 4 (2009): e5233. [doi]
[370]Synthesis and Evaluation of Multivalent Branched HPMA Copolymer\textbackslashtextminusFab´ Conjugates Targeted to the B-Cell Antigen CD20. R N Johnson, P Kopečková, J Kopeček. Bioconjugate Chem.. 20 (2009): 129-137. [doi]
[369]Peptide-directed self-assembly of hydrogels. J Kopeček, J Yang. Acta Biomater. 5 (2009): 805-816. [doi]
[368]Self-Assembling Diblock Copolymers of Poly[N-(2-hydroxypropyl)methacrylamide] and a β-Sheet Peptide. L C Radu, J Yang, J Kopeček. Macromol Biosci. 9 (2009): 36-44. [doi]
[367]Coiled-Coil Hydrogels: Effect of Grafted Copolymer Composition and Cyclization on Gelation. K Dušek, M Dušková-Smrčková, J Yang, J Kopeček. Macromolecules. 42 (2009): 2265-2274. [doi]
[366]Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E1 to Promote Bone Formation in Aged, Estrogen-Deficient Rats. S C Miller, H Pan, D Wang, B M Bowman, P Kopečková, J Kopeček. Pharm. Res.. 25 (2008): 2889-2895. [doi]
[365]Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion. W Yuan, J Yang, P Kopečková, J Kopeček. J. Am. Chem. Soc.. 130 (2008): 15760-15761. [doi]
[364]Combination Chemotherapy and Photodynamic Therapy with Fab´ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells. J Hongrapipat, P Kopečková, J Liu, S Prakongpan, J Kopeček. Mol. Pharm. 5 (2008): 696-709. [doi]
[363]Novel HPMA Copolymer-Bound Constructs for Combined Tumor and Mitochondrial Targeting. V Cuchelkar, P Kopečková, J Kopeček. Mol. Pharm. 5 (2008): 776-786. [doi]
[362]Biodistribution and Pharmacokinetic Studies of Bone-Targeting N-(2-Hydroxypropyl)methacrylamide Copolymer\textbackslashtextminusAlendronate Conjugates. H Pan, M Sima, P Kopečková, K Wu, S Gao, J Liu, D Wang, S C Miller, J Kopeček. Mol. Pharm. 5 (2008): 548-558. [doi]
[361]Release of Prostaglandin E1 from N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates by Bone Cells. H Pan, J Liu, Y Dong, M Sima, P Kopečková, M L Brandi, J Kopeček. Macromol Biosci. 8 (2008): 599-605. [doi]
[360]Synthesis and Biological Evaluation of Disulfide-Linked HPMA Copolymer-Mesochlorin e6 Conjugates. V Cuchelkar, P Kopečková, J Kopeček. Macromol Biosci. 8 (2008): 375-383. [doi]
[359]Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and Their Self-Assembly Into Hybrid Hydrogels. K Wu, J Yang, Č Koňák, P Kopečková, J Kopeček. Macromol Chem Phys. 209 (2008): 467-475. [doi]
[358]Dynamic Light Scattering Study of Self-Assembly of HPMA Hybrid Graft Copolymers. J Yang, K Wu, Č Koňák, J Kopeček. Biomacromolecules. 9 (2008): 510-517. [doi]
[357]Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA Copolymer-9-AC conjugate in rats. S-Q Gao, Y Sun, P Kopečková, C M Peterson, J Kopeček. Pharm. Res.. 25 (2008): 218-226. [doi]
[356]Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. J Hongrapipat, P Kopečková, S Prakongpan, J Kopeček. Int J Pharm. 351 (2008): 259-270. [doi]
[355]Multifunctional water-soluble polymers for drug delivery. H Pan, J Kopeček. Multifunctional Pharmaceutical Nanocarriers. Ed. V P Torchilin. (2008): 81-142.
[354]Genetically Engineered Block Copolymers: Influence of the Length and Structure of the Coiled-Coil Blocks on Hydrogel Self-Assembly. C Xu, J Kopeček. Pharm. Res.. 25 (2008): 674-682. [doi]
[353]Stability in Plasmas of Various Species of HPMA Copolymer–PGE1 Conjugates. H Pan, P Kopečková, J Liu, D Wang, S C Miller, J Kopeček. Pharm. Res.. 24 (2007): 2270-2280. [doi]
[352]Hydrogel biomaterials: A smart future?. J Kopeček. Biomaterials. 28 (2007): 5185-5192. [doi]
[351]Osteotropic peptide that differentiates functional domains of the skeleton. D Wang, S C Miller, L S Shlyakhtenko, Alexander M Portillo, X-M Liu, K Papangkorn, P Kopečková, Yuri Lyubchenko, W I Higuchi, J Kopeček. Bioconjugate Chem.. 18 (2007): 1375-1378. [doi]
[350]Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells. A Malugin, P Kopečková, J Kopeček. J Control Release. 124 (2007): 6-10. [doi]
[349]Self-association properties of HPMA copolymers containing an amphipathic heptapeptide. H Ding, P Kopečková, J Kopeček. J Drug Target. 15 (2007): 465-474. [doi]
[348]Polymeric biomaterials and drug delivery systems. J Kopeček. J. Jpn. Biomat. Soc.. 25 (2007): 123-135.
[347]Hydrogels as smart biomaterials. J Kopeček, J Yang. Polymer Int. 56 (2007): 1078-1098. [doi]
[346]Biodistribution and phannacokinetics of colon-specific HPMA copolymer-9-aminocamptothecin conjugate in mice. S-Q Gao, Z-R Lu, P Kopečková, J Kopeček. J Control Release. 117 (2007): 179-185. [doi]
[345]Self-Assembling Hydrogels. C Xu, J Kopeček. Polym Bull.. 58 (2007): 53-63. [doi]
[344]Using N-(2-hydroxypropyl) methacrylamide copolymer drug bioconjugate as a novel approach to deliver a Bcl-2-targeting compound HA14-1 in vivo. M Oman, J H Liu, J Chen, D Durrant, H.-S. Yang, Y He. Gene Ther Mol Biol \textbackslashldots. (2006):.
[343]Pharmacokinetic and Biodistribution Studies of a Bone-Targeting Drug Delivery System Based on N-(2-Hydroxypropyl)methacrylamide Copolymers. D Wang, M Sima, R L Mosley, J P Davda, N Tietze, S C Miller, P R Gwilt, P Kopečková, J Kopeček. Mol. Pharm. 3 (2006): 717-725. [doi]
[342]Two-Step Fluorescence Screening of CD21-Binding Peptides with One-Bead One-Compound Library and Investigation of Binding Properties of N-(2-Hydroxypropyl)methacrylamide Copolymer\textbackslashtextminusPeptide Conjugates. Hui Ding, Wolfgang M Prodinger, J and Kopeček. Biomacromolecules. 7 (2006): 3037-3046. [doi]
[341]Semitelechelic HPMA Copolymers Functionalized with Triphenylphosphonium as Drug Carriers for Membrane Transduction and Mitochondrial Localization. J Callahan, J Kopeček. Biomacromolecules. 7 (2006): 2347-2356. [doi]
[340]Refolding Hydrogels Self-Assembled from N-(2-Hydroxypropyl)methacrylamide Graft Copolymers by Antiparallel Coiled-Coil Formation. J Yang, C Xu, C Wang, J Kopeček. Biomacromolecules. 7 (2006): 1187-1195. [doi]
[339]Identification of CD21-Binding Peptides with Phage Display and Investigation of Binding Properties of HPMA Copolymer\textbackslashtextminusPeptide Conjugates. H Ding, W M Prodinger, J Kopeček. Bioconjugate Chem.. 17 (2006): 514-523. [doi]
[338]Water-soluble HPMA copolymer – prostaglandin E-1 conjugates containing a cathepsin K sensitive spacer. H Pan, P Kopečková, D Wang, J Yang, S C Miller, J Kopeček. J Drug Target. 14 (2006): 425-435. [doi]
[337]Hybrid Hydrogels Self-Assembled from HPMA Copolymers Containing Peptide Grafts. J Yang, C Xu, P Kopečková, J Kopeček. Macromol Biosci. 6 (2006): 201-209. [doi]
[336]HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Ovarian Carcinoma Cells by the Disruption of Mitochondrial Function. A Malugin, P Kopečková, J Kopeček. Mol. Pharm. 3 (2006): 351-361. [doi]
[335]Polymer-Drug Conjugates. V Cuchelkar, J Kopeček. Polymers in Drug Delivery. Ed. I F Uchegbu. (2006): 155-182.
[334]Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. S-Q Gao, Z-R Lu, B Petri, P Kopečková, J Kopeček. J Control Release. 110 (2006): 323-331. [doi]
[333]Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels. P Chivukula, K Dušek, D Wang, M Dukova-Smrckova, P Kopečková, J Kopeček. Biomaterials. 27 (2006): 1140-1151. [doi]
[332]PEGylation of Poly(ethylene imine) Affects Stability of Complexes with Plasmid DNA under in Vivo Conditions in a Dose-Dependent Manner after Intravenous Injection into Mice. T Merdan, K Kunath, H Petersen, U Bakowsky, K H Voigt, J Kopeček, T Kissel. Bioconjugate Chem.. 16 (2005): 785-792. [doi]
[331]Confocal-microscopy studies of a model oligoribonucleotide HIV inhibitor. R M Hyde, K D Jensen, J Kopeček, Arthur D Broom. Nucleosides Nucleotides Nucleic Acids. 24 (2005): 1875-1884. [doi]
[330]Reversible Hydrogels from Self-Assembling Genetically Engineered Protein Block Copolymers. C Xu, V Breedveld, J Kopeček. Biomacromolecules. 6 (2005): 1739-1749. [doi]
[329]Bone-targeting macromolecular therapeutics. D Wang, S C Miller, P Kopečková, J Kopeček. Adv. Drug. Deliv. Rev.. 57 (2005): 1049-1076. [doi]
[328]Intracellular targeting of polymer-bound drugs for cancer chemotherapy. A Nori, J Kopeček. Adv. Drug. Deliv. Rev.. 57 (2005): 609-636. [doi]
[327]Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics. S C Miller, D Wang, P Kopečková, J Kopeček. J. Bone Miner. Metab.. 23 (2005): 103-108. [doi]
[326]Drug Carriers in Medicine and Biology. Peter D Senter, J Kopeček. Mol. Pharm. 1 (2004): 395-398. [doi]
[325]Genetically Engineered Protein Motifs in the Design of Novel Polymers and Drug Delivery Systems. J Kopeček. Contemporary Topics in Advanced Polymer Science and Technology. Eds. Q F Zhou, S Z D Cheng. (2004): 374-386.
[324]The Arthrotropism of Macromolecules in Adjuvant-Induced Arthritis Rat Model: A Preliminary Study. D Wang, S C Miller, M Sima, D Parker, H Buswell, K C Goodrich, P Kopečková, J Kopeček. Pharm. Res.. 21 (2004): 1741-1749. [doi]
[323]HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Human Ovarian Carcinoma Cells by a Fas-Independent Pathway. A Malugin, P Kopečková, J Kopeček. Mol. Pharm. 1 (2004): 174-182. [doi]
[322]Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis. D Wang, W Li, M Pechar, P Kopečková, D Bromme, J Kopeček. Int J Pharm. 277 (2004): 73-79. [doi]
[321]Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer–doxorubicin conjugates to human colon cancer cells. A David, P Kopečková, T Minko, A Rubinstein, J Kopeček. Eur J Cancer. 40 (2004): 148-157. [doi]
[320]Synthesis and Evaluation of Water-Soluble Polymeric Bone-Targeted Drug Delivery Systems. D Wang, S Miller, M Sima, P Kopečková, J Kopeček. Bioconjugate Chem.. 14 (2003): 853-859. [doi]
[319]Swelling Pressure Induced Phase-Volume Transition in Hybrid Biopolymer Gels Caused by Unfolding of Folded Crosslinks: A Model. K Dušek, M Dušková-Smrčková, Michal Ilavský, R Stewart, J Kopeček. Biomacromolecules. 4 (2003): 1818-1826. [doi]
[318]Pegylated Polyethylenimine\textbackslashtextminusFab‘ Antibody Fragment Conjugates for Targeted Gene Delivery to Human Ovarian Carcinoma Cells. T Merdan, J Callahan, H Petersen, K Kunath, U Bakowsky, P Kopečková, T Kissel, J Kopeček. Bioconjugate Chem.. 14 (2003): 989-996. [doi]
[317]Free and N-(2-Hydroxypropyl)methacrylamide Copolymer-bound Geldanamycin Derivative Induce Different Stress Responses in A2780 Human Ovarian Carcinoma Cells. Nobuhiro Nishiyama, A Nori, Alexander Malugin, Y Kasuya, P Kopečková, J Kopeček. Cancer Res.. 63 (2003): 7876-7882. [doi]
[316]Macromolecular therapeutics: State-of-the-art and future potential. J Kopeček, P Kopečková. Bulletin technique Gattefossé. 96 (2003): 9-21.
[315]Smart and genetically engineered biomaterials and drug delivery systems. J Kopeček. Eur J Pharm Sci. 20 (2003): 1-16. [doi]
[314]Antigen Responsive Hydrogels Based on Polymerizable Antibody Fab´ Fragment. Z-R Lu, P Kopečková, J Kopeček. Macromol Biosci. 3 (2003): 296-300. [doi]
[313]Subcellular trafficking of HPMA copolymer–Tat conjugates in human ovarian carcinoma cells. A Nori, K D Jensen, M Tijerina, P Kopečková, J Kopeček. J Control Release. 91 (2003): 53-59. [doi]
[312]Mechanisms of Cytotoxicity in Human Ovarian Carcinoma Cells Exposed to Free Mce6 or HPMA Copolymer–Mce6 Conjugates. M Tijerina, P Kopečková, J Kopeček. Photochem. Photobiol.. 77 (2003): 645-652. [doi]
[311]Correlation of Subcellular Compartmentalization of HPMA Copolymer-Mce6 Conjugates with Chemotherapeutic Activity in Human Ovarian Carcinoma Cells. M Tijerina, P Kopečková, J Kopeček. Pharm. Res.. 20 (2003): 728-737. [doi]
[310]HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer. C M Peterson, J.-G. Shiah, Y Sun, P Kopečková, T Minko, R C Straight, J Kopeček. Adv. Exp. Med. Biol.. 519 (2003): 101-123.
[309]Binding and cytotoxicity of HPMA copolymer conjugates to lymphocytes mediated by receptor-binding epitopes. A Tang, P Kopečková, J Kopeček. Pharm. Res.. 20 (2003): 360-367. [doi]
[308]Tat-Conjugated Synthetic Macromolecules Facilitate Cytoplasmic Drug Delivery To Human Ovarian Carcinoma Cells. A Nori, K Jensen, M Tijerina, P Kopečková, J Kopeček. Bioconjugate Chem.. 14 (2003): 44-50. [doi]
[307]Cytoplasmic delivery and nuclear targeting of synthetic macromolecules. K D Jensen, A Nori, M Tijerina, P Kopečková, J Kopeček. J Control Release. 87 (2003): 89-105. [doi]
[306]Polymerizable Fab’ antibody fragment targeted photodynamic cancer therapy in nude mice. Z-R Lu, J.-G. Shiah, P Kopečková, J Kopeček. STP pharma sciences. 13 (2003): 69-75.
[305]N-(2-hydroxypropyl)-methacrylamide copolymer-9-aminocamptothecin conjugate: Colon-specific drug delivery in rats. Shinji Sakuma, Z-R Lu, B Pecharova, P Kopečková, J Kopeček. J Bioact Compat Polym. 17 (2002): 305-319. [doi]
[304]Novel Aromatic Azo-Containing pH-Sensitive Hydrogels: Synthesis and Characterization. D Wang, K Dušek, P Kopečková, M Dušková-Smrčková, J Kopeček. Macromolecules. 35 (2002): 7791-7803. [doi]
[303]Antisense Oligonucleotides Delivered to the Lysosome Escape and Actively Inhibit the Hepatitis B Virus. K Jensen, P Kopečková, J Kopeček. Bioconjugate Chem.. 13 (2002): 975-984. [doi]
[302]Polymer chemistry: Swell gels. J Kopeček. Nature. 417 (2002): 388-391. [doi]
[301]Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. T Merdan, J Kopeček, T Kissel. Adv. Drug. Deliv. Rev.. 54 (2002): 715-758. [doi]
[300]Inhibition of Cathepsin K with Lysosomotropic Macromolecular Inhibitors. D Wang, M Pechar, Weijie Li, P Kopečková, D Brömme, J Kopeček. Biochemistry. 41 (2002): 8849-8859. [doi]
[299]Associative diblock copolymers of poly(ethylene glycol) and coiled-coil peptides. M Pechar, P Kopečková, L Joss, J Kopeček. Macromol Biosci. 2 (2002): 199-206. 3.0.CO;2-2″ rel=”noreferrer noopener”>[doi]
[298]Intracellular Processing of Poly(Ethylene Imine)/Ribozyme Complexes Can Be Observed in Living Cells by Using Confocal Laser Scanning Microscopy and Inhibitor Experiments. T Merdan, K Kunath, D Fischer, J Kopeček, T Kissel. Pharm. Res.. 19 (2002): 140-146. [doi]
[297]The Influence of Fusion Sequences on the Thermal Stabilities of Coiled-Coil Proteins. C Xu, L Joss, C Wang, M Pechar, J Kopeček. Macromol Biosci. 2 (2002): 395-401. 3.0.CO;2-9″ rel=”noreferrer noopener”>[doi]
[296]Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Yi Luo, Nicole J Bernshaw, Z-R Lu, J Kopeček, G D Prestwich. Pharm. Res.. 19 (2002): 396-402. [doi]
[295]Presentation of Epitopes on Genetically Engineered Peptides and Selection of Lymphoma-Targeting Moieties Based on Epitope Biorecognition. A Tang, J Kopeček. Biomacromolecules. 3 (2002): 421-431. [doi]
[294]The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in hep G2 cells. K D Jensen, P Kopečková, J H Bridge, J Kopeček. AAPS PharmSci. 3 (2002): 62-75. [doi]
[293]Design of novel bioconjugates for targeted drug delivery. Z-R Lu, J.-G. Shiah, Shinji Sakuma, P Kopečková, J Kopeček. J Control Release. 78 (2002): 165-173. [doi]
[292]Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. Y Kasuya, Z-R Lu, P Kopečková, S E Tabibi, J Kopeček. Pharm. Res.. 19 (2002): 115-123. [doi]
[291]The Role of Galactose, Lactose, and Galactose Valency in the Biorecognition of N-(2-Hydroxypropyl)Methacrylamide Copolymers by Human Colon Adenocarcinoma Cells. A David, P Kopečková, J Kopeček, A Rubinstein. Pharm. Res.. 19 (2002): 1114-1122. [doi]
[290]Poly[N-(2-hydroxypropyl)methacrylamide-block-n-butyl acrylate] micelles in water/DMF mixed solvents. Č Koňák, B Ganchev, M Teodorescu, K Matyjaszewski, P Kopečková, J Kopeček. Polymer. 43 (2002): 3735-3741. [doi]
[289]Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. Shinji Sakuma, Z-R Lu, P Kopečková, J Kopeček. J Control Release. 75 (2001): 365-379. [doi]
[288]Enhanced Biorecognition and Internalization of HPMA Copolymers Containing Multiple or Multivalent Carbohydrate Side-Chains by Human Hepatocarcinoma Cells. A David, P Kopečková, A Rubinstein, J Kopeček. Bioconjugate Chem.. 12 (2001): 890-899. [doi]
[287]Hybrid Hydrogels Cross-Linked by Genetically Engineered Coiled-Coil Block Proteins. C Wang, J Kopeček, R J Stewart. Biomacromolecules. 2 (2001): 912-920. [doi]
[286]Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions. S Wróblewski, M M Berenson, P Kopečková, J Kopeček. J Control Release. 74 (2001): 283-293. [doi]
[285]Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer–doxorubicin/mesochlorin e6-OV-TL 16 antibody immunoconjugates. J.-G. Shiah, Y Sun, P Kopečková, C M Peterson, R C Straight, J Kopeček. J Control Release. 74 (2001): 249-253. [doi]
[284]Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo. L Varticovski, Z-R Lu, K Mitchell, Isabel de Aos, J Kopeček. J Control Release. 74 (2001): 275-281. [doi]
[283]Preparation of Fab’ from Murine IgG2a for Thiol Reactive Conjugation. K D Fowers, J Callahan, Parke Byron, JindřIch ich Kopeček. J Drug Target. 9 (2001): 281-294. [doi]
[282]Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems. Y Kasuya, Z-R Lu, P Kopečková, J Kopeček. Bioorg. Med. Chem. Lett.. 11 (2001): 2089-2091. [doi]
[281]The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce6 conjugates in a human ovarian carcinoma. M Tijerina, P Kopečková, J Kopeček. J Control Release. 74 (2001): 269-273. [doi]
[280]A model for swelling changes in a covalently crosslinked gel caused by unfolding of folded domains. K Dušek, M Dušková-Smrčková, R J Stewart, J Kopeček. Polym Bull.. 47 (2001): 351-358. [doi]
[279]Preparation and biological evaluation of polymerizable antibody Fab´ fragment targeted polymeric drug delivery system. Z-R Lu, J.-G. Shiah, P Kopečková, J Kopeček. J Control Release. 74 (2001): 263-268. [doi]
[278]Synthesis and characterization of HPMA copolymer–aminopropylgeldanamycin conjugates. Y Kasuya, Z-R Lu, P Kopečková, T Minko, S E Tabibi, J Kopeček. J Control Release. 74 (2001): 203-211. [doi]
[277]Water soluble polymers in tumor targeted delivery. J Kopeček, P Kopečková, T Minko, Z-R Lu, C M Peterson. J Control Release. 74 (2001): 147-158. [doi]
[276]De novo design of biomedical polymers: hybrids from synthetic macromolecules and genetically engineered protein domains. J Kopeček, A Tang, C Wang, R J Stewart. Macromol. Symp.. 174 (2001): 31-42. 3.0.CO;2-6″ rel=”noreferrer noopener”>[doi]
[275]The Influence of a Colonic Microbiota on HPMA Copolymer Lectin Conjugates Binding in Rodent Intestine. S Wróblewski, B R̆íhová, P Rossmann, T Hudcovicz, Z Rehakova, P Kopečková, J Kopeček. J Drug Target. 9 (2001): 85-94. [doi]
[274]Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers. Z-R Lu, S-Q Gao, P Kopečková, J Kopeček. Bioconjugate Chem.. 12 (2001): 129-133. [doi]
[273]Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. T Minko, P Kopečková, J Kopeček. J Control Release. 71 (2001): 227-237. [doi]
[272]Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer–doxorubicin conjugates in nude mice. J.-G. Shiah, M Dvorak, P Kopečková, Y Sun, C M Peterson, J Kopeček. Eur J Cancer. 37 (2001): 131-139. [doi]
[271]The coiled coils in the design of protein-based constructs: hybrid hydrogels and epitope displays. A Tang, C Wang, R J Stewart, J Kopeček. J Control Release. 72 (2001): 57-70. [doi]
[270]Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin. T Minko, P Kopečková, J Kopeček. Macromol. Symp.. 172 (2001): 35-48. 3.0.CO;2-N” rel=”noreferrer noopener”>[doi]
[269]Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide] for Biomedical Applications. Z-R Lu, P Kopečková, J Kopeček. Polymeric Drugs & Delivery Systems. Eds. R M Ottenbrite, S-W Kim. Technomics Publishing Co. (2001): 1-14.
[268]Genetically Engineered Protein Domain as Crosslinks in Hydrogels. C Wang, R J Stewart, J Kopeček. Polymeric Drugs & Delivery Systems. Eds. R M Ottenbrite, S-W Kim. (2001): 131-143.
[267]Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance. M Tijerina, K D Fowers, P Kopečková, J Kopeček. Biomaterials. 21 (2000): 2203-2210. [doi]
[266]Synthesis of Starlike N-(2-Hydroxypropyl)methacrylamide Copolymers: Potential Drug Carriers\textbackslashdag. D Wang, P Kopečková, T Minko, V Nanayakkara, J Kopeček. Biomacromolecules. 1 (2000): 313-319. [doi]
[265]Responsive Hybrid Hydrogels with Volume Transitions Modulated by a Titin Immunoglobulin Module. L Chem, J Kopeček, R Stewart. Bioconjugate Chem.. 11 (2000): 734-740. [doi]
[264]Biorecognition of HPMA copolymer–lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues. S Wróblewski, M M Berenson, P Kopečková, J Kopeček. J. Biomed. Mater. Res.. 51 (2000): 329-342. 3.0.CO;2-0″ rel=”noreferrer noopener”>[doi]
[263]Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. M Demoy, T Minko, P Kopečková, J Kopeček. J Control Release. 69 (2000): 185-196. [doi]
[262]HPMA copolymer-anticancer drug conjugates: Design, activity, and mechanism of action. J Kopeček, P Kopečková, T Minko, Z-R Lu. Eur J Pharm Biopharm. 50 (2000): 61-81. [doi]
[261]The Influence of Cytotoxicity of Macromolecules and of VEGF Gene Modulated Vascular Permeability on the Enhanced Permeability and Retention Effect in Resistant Solid Tumors. T Minko, P Kopečková, Vitaliy Pozharov, K D Jensen, J Kopeček. Pharm. Res.. 17 (2000): 505-514. [doi]
[260]Self-Assembled Peptides Exposing Epitopes Recognizable by Human Lymphoma Cells. A Tang, C Wang, R Stewart, J Kopeček. Bioconjugate Chem.. 11 (2000): 363-371. [doi]
[259]Synthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates. Z-R Lu, S-Q Gao, P Kopečková, J Kopeček. Bioconjugate Chem.. 11 (2000): 3-7. [doi]
[258]Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. T Minko, P Kopečková, J Kopeček. Int. J. Cancer. 86 (2000): 108-117. 3.0.CO;2-8″ rel=”noreferrer noopener”>[doi]
[257]HPMA copolymer-modified avidin: Immune response. P R Hart, P Kopečková, V Omelyanenko, E Enioutina, J Kopeček. J Biomater Sci Polym Ed. 11 (2000): 1-12. [doi]
[256]Antitumor Activity of N-(2-Hydroxypropyl)methacrylamide Copolymer-Mesochlorin e6 and Adriamycin Conjugates in Combination Treatments. J.-G. Shiah, Y Sun, C M Peterson, R C Straight, J Kopeček. Clin. Cancer Res.. 6 (2000): 1008-1015. [doi]
[255]Photodynamic cross-linking of proteins: V. Nature of the tyrosine–tyrosine bonds formed in the FMN-sensitized intermolecular cross-linking of N-acetyl-L-tyrosine. H.-R. Shen, J D Spikes, C J Smith, J Kopeček. J Photochem Photobiol A Chem. 133 (2000): 115-122. [doi]
[254]HPMA copolymer–anticancer drug–OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound Adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line. K Kunath, P Kopečková, T Minko, J Kopeček. Eur J Pharm Biopharm. 49 (2000): 11-15. [doi]
[253]Cooperativity between free and N-(2-hydroxypropyl) methacrylamide copolymer bound adriamycin and mesochlorin e6 monoethylene diamine induced photodynamic therapy in human epithelial ovarian carcinoma in vitro. J M Lu, C M Peterson, J Guo-Shiah, Z-W Gu, C A Peterson, R C Straight, J Kopeček. Int. J. Oncol.. 15 (1999): 5-16.
[252]Synthesis of HPMA copolymer containing adriamycin bound via an acid-labile spacer and its activity toward human ovarian carcinoma cells. W-M Choi, P Kopečková, T Minko, J Kopeček. J Bioact Compat Polym. 14 (1999): 447-456.
[251]Biodistribution of free and N-(2-hydroxypropyl)methacrylamide copolymer-bound mesochlorin e6 and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts. J.-G. Shiah, Y Sun, C M Peterson, J Kopeček. J Control Release. 61 (1999): 145-157. [doi]
[250]Polymerizable Fab’ antibody fragments for targeting of anticancer drugs. Z-R Lu, P Kopečková, J Kopeček. Nat. Biotechnol.. 17 (1999): 1101-1104.
[249]High-molecular weight HPMA copolymer–adriamycin conjugates. M Dvorak, P Kopečková, J Kopeček. J Control Release. 60 (1999): 321-332. [doi]
[248]Photodynamic cross-linking of proteins: IV. Nature of the His–His bond(s) formed in the rose bengal-photosensitized cross-linking of N-benzoyl-L-histidine. H.-R. Shen, J D Spikes, C J Smith, J Kopeček. J Photochem Photobiol A Chem. 130 (1999): 1-6. [doi]
[247]Synthesis of semitelechelic poly[N-(2-hydroxypropyl)methacryl-amide] by radical polymerization in the presence of alkyl mercaptans. Z-R Lu, P Kopečková, Z Wu, J Kopeček. Macromol Chem Phys. 200 (1999): 2022-2030. 3.0.CO;2-Y” rel=”noreferrer noopener”>[doi]
[246]Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells. T Minko, P Kopečková, J Kopeček. Pharm. Res.. 16 (1999): 986-996. [doi]
[245]Biorecognition of HPMA Copolymer-Adriamycin Conjugates by Lymphocytes Mediated by Synthetic Receptor Binding Epitopes. V Omelyanenko, P Kopečková, R K Prakash, C D Ebert, J Kopeček. Pharm. Res.. 16 (1999): 1010-1019. [doi]
[244]Photodynamic crosslinking of proteins. III. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecular crosslinking of model tyrosine-containing N-(2-hydroxypropyl)methacrylamide copolymers. J D Spikes, H.-R. Shen, P Kopečková, J Kopeček. Photochem. Photobiol.. 70 (1999): 130-137. [doi]
[243]Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. C Wang, R J Stewart, J Kopeček. Nature. 397 (1999): 417-420. [doi]
[242]Degradation and Aggregation of Human Calcitonin In Vitro. Richard H Lu, P Kopečková, J Kopeček. Pharm. Res.. 16 (1999): 359-367. [doi]
[241]Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line. T Minko, P Kopečková, J Kopeček. J Control Release. 59 (1999): 133-148. [doi]
[240]Functionalized semitelechelic poly(N-(2-hydroxypropyl)methacrylamide) for protein modification. Z-R Lu, P Kopečková, Z Wu, J Kopeček. Bioconjugate Chem.. 9 (1998): 793-804. [doi]
[239]Micellization of Graft Copolymers of Alkyl Methacrylates with α-Methyl-\$ømega\$-hydroxypoly(oxyethylene) Methacrylates. C Konák, M Helmstedt, P Kopečková, J Kopeček. J Colloid Interface Sci. 208 (1998): 252-258. [doi]
[238]Photoassociation of water-soluble copolymers containing photochromic spirobenzopyran moieties. Č Koňák, R C Rathi, P Kopečková, J Kopeček. Polym Adv Technol. 9 (1998): 641-648. 3.0.CO;2-W” rel=”noreferrer noopener”>[doi]
[237]Lectin-HPMA copolymer conjugates: potential oral drug carriers for targeting diseased tissues. S Wróblewski, P Kopečková, B R̆íhová, J Kopeček. Macromol Chem Phys. 199 (1998): 2601-2608. 3.0.CO;2-9″ rel=”noreferrer noopener”>[doi]
[236]Novel pH-sensitive hydrogels with adjustable swelling kinetics. Emmanuel O Akala, P Kopečková, J Kopeček. Biomaterials. 19 (1998): 1037-1047. [doi]
[235]Influence of pH on aggregation and photoproperties of n-(2-hydroxypropyl)methacrylamide copolymer–meso-chlorin e6 conjugates. J.-G. Shiah, C Konák, J D Spikes, J Kopeček. . 5 (1998): 119-126. [doi]
[234]HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line. T Minko, P Kopečková, V Pozharov, J Kopeček. J Control Release. 54 (1998): 223-233. [doi]
[233]HPMA-copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. V Omelyanenko, C Gentry, P Kopečková, J Kopeček. Int. J. Cancer. 75 (1998): 600-608. 3.0.co;2-c” rel=”noreferrer noopener”>[doi]
[232]Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. V Omelyanenko, P Kopečková, C Gentry, J Kopeček. J Control Release. 53 (1998): 25-37. [doi]
[231]Biorecognizable Polymers: Design, Structure, and Bioactivity. J Kopeček, P Kopečková, C Konák. J. Macromol. Sci., Pure Appl. Chem.. 34 (1997): 2103-2117. [doi]
[230]Solution and Photoproperties of N-(2-Hydroxypropyl)methacrylamide Copolymer\textbackslashtextminusMeso-chlorin e6 Conjugates. J.-G. Shiah, Č Koňák, J D Spikes, J Kopeček. J. Phys. Chem. B. 101 (1997): 6803-6809. [doi]
[229]Photoregulated Association of Water-Soluble Copolymers with Spirobenzopyran-Containing Side Chains. Č Koňák, Ramesh C Rathi, P Kopečková, J Kopeček. Macromolecules. 30 (1997): 5553-5556. [doi]
[228]Development of a fibrinolytic surface: specific and non-specific binding of plasminogen. K D Fowers, J Kopeček. Colloids Surf B Biointerfaces. 9 (1997): 315-330. [doi]
[227]Size-dependent permeability of hydrophilic probes across rabbit colonic epithelium. H Ghandehari, P L Smith, H Ellens, P.-Y. Yeh, J Kopeček. J. Pharmacol. Exp. Ther.. 280 (1997): 747-753.
[226]In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds. H Ghandehari, P Kopečková, J Kopeček. Biomaterials. 18 (1997): 861-872. [doi]
[225]Biorecognition of sugar containing N-(2-hydroxypropyl)methacrylamide copolymers by immobilized lectin. R C Rathi, P Kopečková, J Kopeček. Macromol Chem Phys. 198 (1997): 1165-1180. [doi]
[224]Lysosomal degradability of poly(alpha-amino acids). H-C Chiu, P Kopečková, S S Deshmane, J Kopeček. J. Biomed. Mater. Res.. 34 (1997): 381-392. 3.0.co;2-j” rel=”noreferrer noopener”>[doi]
[223]Intracellularly biorecognizable derivatives of 5-fluorouracil: Implications for site-specific delivery in the human condition. D A Putnam, J.-G. Shiah, J Kopeček. Biochem. Pharmacol.. 52 (1996): 957-962. [doi]
[222]Photodynamic crosslinking of proteins II. Photocrosslinking of a model protein-ribonuclease A. H.-R. Shen, J D Spikes, P Kopečková, J Kopeček. J. Photochem. Photobiol. B, Biol.. 35 (1996): 213-219. [doi]
[221]Photodynamic crosslinking of proteins. I. Model studies using histidine- and lysine-containing N-(2-hydroxypropyl) methacrylamide copolymers. H.-R. Shen, J D Spikes, P Kopečková, J Kopeček. J. Photochem. Photobiol. B, Biol.. 34 (1996): 203-210. [doi]
[220]Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl)methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice. C M Peterson, J M Lu, Y Sun, C A Peterson, J.-G. Shiah, R C Straight, J Kopeček. Cancer Res.. 56 (1996): 3980-3985.
[219]HPMA Copolymer-Anticancer Drug-OV-TL16 Antibody Conjugates. 1. Influence of the Method of Synthesis on the Binding Affinity to OVCAR-3 Ovarian Carcinoma Cells in Vitro. V Omelyanenko, P Kopečková, C Gentry, J.-G. Shiah, J Kopeček. J Drug Target. 3 (1996): 357-373. [doi]
[218]Biorecognizable Biomedical Polymers. J Kopeček, P Kopečková, V Omelyanenko. Advances in Biomedical Polymers in Biomedical Engineering and Drug Delivery Systems. Eds. N Ogata, S-W Kim, J Feijen, T Okano. (1996): 91-95.
[217]Biodegradable and pH sensitive hydrogels: synthesis by a polymer-polymer reaction. H Ghandehari, P Kopečková, P.-Y. Yeh, J Kopeček. Macromol Chem Phys. 197 (1996): 965-980. [doi]
[216]Isobolographic Assessment of the Interaction Between Adriamycin and Photodynamic Therapy With Meso-Chlorin e6 Monoethylene Diamine in Human Epithelial Ovarian Carcinoma (OVCAR-3) In Vitro. C M Peterson, M L Jing, G Zhong-wei, S Jane-Guo, K Lythgoe, C A Peterson, R C Straight, J Kopeček. J. Soc. Gynecol. Investig.. 2 (1995): 772-777. [doi]
[215]Enantioselective Release of 5-Fluorouracil from N-(2-Hydroxypropyl)methacrylamide-Based Copolymers via Lysosomal Enzymes. D Putnam, J Kopeček. Bioconjugate Chem.. 6 (1995): 483-492. [doi]
[214]Association of a Substituted Zinc(II) Phthalocyanine-N- (2-Hydroxypropyl)methacrylamide Copolymer Conjugate. Z-W Gu, V Omelyanenko, P Kopečková, J Kopeček, Č Koňák. Macromolecules. 28 (1995): 8375-8380. [doi]
[213]Association of Graft Copolymers of Alkyl Methacrylates with α-Methyl-\$ømega\$-hydroxy-poly(oxyethylene) ethacrylates. Č Koňák, Z Tuzar, P Kopečková, J D Andrade, J Kopeček. CCCC. 60 (1995): 1971-1985. [doi]
[212]Degradability of hydrogels containing azoaromatic crosslinks. P.-Y. Yeh, P Kopečková, J Kopeček. Macromol Chem Phys. 196 (1995): 2183-2202. [doi]
[211]Prolonged Blood Circulation in Rats of Nanospheres Surface-Modified with Semitelechelic Poly[N-(2-Hydroxypropyl)methacrylamide]. S Kamei, J Kopeček. Pharm. Res.. 12 (1995): 663-668. [doi]
[210]Site-specific drug delivery and penetration enhancement in the gastrointestinal tract. P.-Y. Yeh, M M Berenson, W S Samowitz, P Kopečková, J Kopeček. J Control Release. 36 (1995): 109-124. [doi]
[209]Polymer conjugates with anticancer activity. D A Putnam, J Kopeček. Advances in Polymer Science; Biopolymers II. Eds. N A Peppas, R S Langer. (1995): 55-123.
[208]Enzymatic Degradation of Poly(ethylene glycol) Modified Dextrans. H-C Chiu, Č Koňák, P Kopečková, J Kopeček. J Bioact Compat Polym. 9 (1994): 388-410. [doi]
[207]Photoregulated Adsorption and Association of Amphiphilic Copolymers Containing Azobenzene Side Chains. Č Koňák, P Kopečková, J Kopeček. J Colloid Interface Sci. 168 (1994): 235-241. [doi]
[206]Solution Properties of Polymers Containing Zwitterionic Moieties in Side Chains. Č Koňák, R C Rathi, P Kopečková, J Kopeček. Macromolecules. 27 (1994): 1992-1996. [doi]
[205]Biodegradable and pH-sensitive hydrogels: Synthesis by crosslinking of N,N-dimethylacrylamide copolymer precursors. P.-Y. Yeh, P Kopečková, J Kopeček. J Polym Sci A Polym Chem. 32 (1994): 1627-1637. [doi]
[204]Adsorption and activation of zymogens at solid-liquid interfaces: I. Chymotrypsinogen on alkylamino modified silica derivatives. H.-R. Yen, Sven Oscarsson, K Ulbrich, J Kopeček. J. Biomed. Mater. Res.. 28 (1994): 247-257. [doi]
[203]Bioadhesive N-(2-hydroxypropyl)methacrylamide copolymers for colon-specific drug delivery. P Kopečková, R C Rathi, S Takada, B R̆íhová, M M Berenson, J Kopeček. J Control Release. 28 (1994): 211-222. [doi]
[202]A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light. N L Krinick, Y Sun, D Joyner, J D Spikes, R C Straight, J Kopeček. J Biomater Sci Polym Ed. 5 (1994): 303-324. [doi]
[201]Synthesis and Photoproperties of a Substituted Zinc(II) Phthalocyanine-\textitN-(2-hydroxypropyl)methacrylamide Copolymer Conjugate. Z-W Gu, J D Spikes, P Kopečková, J Kopeček. CCCC. 58 (1993): 2321-2336. [doi]
[200]Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates. H-C Chiu, S Zalipsky, P Kopečková, J Kopeček. Bioconjugate Chem.. 4 (1993): 290-295. [doi]
[199]Photoproperties of a mesochlorin e6—N-(2-hydroxypropyl)methacrylamide copolymer conjugate. J D Spikes, N L Krinick, J Kopeček. J Photochem Photobiol A Chem. 70 (1993): 163-170. [doi]
[198]Effect of side-chains on solution properties of N-(2-hydroxypropyl)methacrylamide copolymers in aqueous solvents. Č Koňák, R C Rathi, P Kopečková, J Kopeček. Polymer. 34 (1993): 4767-4773. [doi]
[197]Targetable photoactivatable drugs: 3. In vitro efficacy of polymer bound chlorin e-6 toward human hepatocarcinoma cell line (PLC/PRF/5) targeted with galactosamine and to mouse splenocytes targeted with anti-Thy 1.2 antibodies. B R̆íhová, N L Krinick, J Kopeček. J Control Release. 25 (1993): 71-87. [doi]
[196]Degradation of proteins by guinea pig intestinal enzymes. K Ikesue, P Kopečková, J Kopeček. Int J Pharm. 95 (1993): 171-179. [doi]
[195]In vitro bioadhesion of carbohydrate-containing N-(2-hydroxypropyl) methacrylamide copolymers to the GI tract of guinea pigs. B Rihova, R C Rathi, P Kopečková, J Kopeček. Int J Pharm. 87 (1992): 105-116.
[194]Photoregulated association of N-(2-hydroxypropyl)methacrylamide copolymers with azobenzene-containing side chains. Č Koňák, P Kopečková, J Kopeček. Macromolecules. 25 (1992): 5451-5456. [doi]
[193]Hydrogels for Site-Specific Drug Delivery to the Colon: In Vitro and in Vivo Degradation. Helle Brøndsted, J Kopeček. Pharm. Res.. 9 (1992): 1540-1545. [doi]
[192]N-(2-Hydroxypropyl)methacrylamide Copolymers for Colon Specific Drug Delivery. J Kopeček, P Kopečková. Oral Colon-Specific Delivery. Ed. D R Friend. (1992): 189-211.
[191]Cleavage of oligopeptide p-nitroanilides attached to N-(2-hydroxypropyl)methacrylamide copolymers by guinea pig intestinal enzymes. P Kopečková, K Ikesue, J Kopeček. Die Makromolekulare Chemie. 193 (1992): 2605-2619. [doi]
[190]pH Sensitive Hydrogels: Characteristics and Potential in Drug Delivery. H Brøndsted, J Kopeček. Polyelectrolyte Gels. Eds. R S Harland, R K Prudhomme. (1992): 285-304.
[189]Polymers for colon-specific drug delivery. J Kopeček, P Kopečková, H Brøndsted, R C Rathi, B R̆íhová, P.-Y. Yeh, K Ikesue. J Control Release. 19 (1992): 121-130. [doi]
[188]Optically controlled ligand delivery: 3. Photocleavage of 2-nitrobenzyl bonds at solid-liquid interfaces. H.-R. Yen, J D Andrade, J Kopeček. Polymer. 33 (1992): 1763-1767. [doi]
[187]Evaluation of protein-N-(2-hydroxypropyl) methacrylamide copolymer conjugates as targetable drug-carriers. 2. Body distribution of conjugates containing transferrin, antitransferrin receptor antibody or anti-Thy 1.2 antibody and effectiveness of transferrin-containing daunomycin conjugates against mouse L1210 leukaemia in vivo. P A Flanagan, R Duncan, V Šubr, K Ulbrich, P Kopečková, J Kopeček. J Control Release. 18 (1992): 25-38. [doi]
[186]Controlled release of LHRH-DT from bioerodible hydrogel microspheres. M Singh, R C Rathi, A Singh, J Heller, G P Talwar, J Kopeček. Int J Pharm. 76 (1991): R5-R8. [doi]
[185]Optically controlled ligand delivery. II. Copolymers containing α-methylphenacyl bonds. H.-R. Yen, J D Andrade, J Kopeček. J Appl Polym Sci. 43 (1991): 1241-1252. [doi]
[184]N-(2-hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties. R C Rathi, P Kopečková, B R̆íhová, J Kopeček. J Polym Sci A Polym Chem. 29 (1991): 1895-1902. [doi]
[183]Intraperitoneal and subcutaneous retention of a soluble polymeric drug-carrier bearing galactose. L W Seymour, R Duncan, V Chytrý, J Strohalm, K Ulbrich, J Kopeček. J Control Release. 16 (1991): 255-262. [doi]
[182]Hydrogels for site-specific oral drug delivery: synthesis and characterization. H Brøndsted, J Kopeček. Biomaterials. 12 (1991): 584-592. [doi]
[181]Enzymatic degradation and immunogenic properties of derivatized dextrans. B Crepon, J Jozefonvicz, V Chytrý, B R̆íhová, J Kopeček. Biomaterials. 12 (1991): 550-554. [doi]
[180]Targetable polymeric anticancer drugs: Temporal control of drug activity. J Kopeček. Ann NY Acad Sci. 618 (1991): 335-344.
[179]Targetable photoactivatable polymeric drugs. J Kopeček, B R̆íhová, N L Krinick. J Control Release. 16 (1991): 137-144. [doi]
[178]Release of p-nitroaniline from oligopeptide side chains attached to N-(2-hydroxypropyl)methacrylamide copolymers during incubation with rat intestinal brush border enzymes. P Kopečková, M A Longer, J F Woodley, R Duncan, J Kopeček. Makromol. Chem. Rapid Commun.. 12 (1991): 101-106. [doi]
[177]Bioadhesive Water-Soluble Polymeric Drug Carriers for Site-Specific Oral Drug Delivery. Y Grim, J Kopeček. New Polymeric Mat.. 3 (1991): 49-59.
[176]Soluble Polymers as Targetable Drug Carriers. N L Krinick, J Kopeček. Handbook of Experimental Pharmacology, Vol. 100, Targeted Drug Delivery. Ed. R L Juliano. (1991): 105-179.
[175]Hydrogels for site-specific oral delivery. Poly[(acrylic acid)-co-(butyl acrylate)] crosslinked with 4,4´-bis(methacryloylamino)azobenzene. Martin Přádný, J Kopeček. Die Makromolekulare Chemie. 191 (1990): 1887-1897. [doi]
[174]Release of 5-aminosalicylic acid from bioadhesive N-(2-hydroxypropyl)methacrylamide copolymers by azoreductases in vitro. P Kopečková, J Kopeček. Die Makromolekulare Chemie. 191 (1990): 2037-2045. [doi]
[173]Release of macromolecules and daunomycin from hydrophilic gels containing enzymatically degradable bonds. V Šubr, R Duncan, J Kopeček. J Biomater Sci Polym Ed. 1 (1990): 261-278. [doi]
[172]Targetable photoactivatable drugs, 2. Synthesis of N-(2-hydroxypropyl)methacrylamide copolymeranti-thy 1.2 antibody-chlorin e6 conjugates and a preliminary study of their photodynamic effect on mouse splenocytes in vitro. N L Krinick, B R̆íhová, K Ulbrich, J Strohalm, J Kopeček. Die Makromolekulare Chemie. 191 (1990): 839-856. [doi]
[171]Immunosensors: Remaining Problems in the Development of Remote, Continuous, Multi-Channel Devices. J D Andrade, J N Lin, V Hlady, J Herron, D Christensen, J Kopeček. Biosensor Technology. Ed. R B Buck. (1990): 219-239.
[170]The Influence of Poly(Ethylene Oxide) Spacers on the Covalent and Non-Specific Binding of Immunoglobulin G to Silica Surfaces. P Kopečková, J Kopeček, J D Andrade. New Polymeric Mat.. 1 (1990): 289-297.
[169]Surface properties of copolymers of alkyl methacrylates with, methoxy (polyethylene oxide) metiiacrylates and their application as protein-resistant coatings. Jin Ho Lee, P Kopečková, J Kopeček, J D Andrade. Biomaterials. 11 (1990): 455-464. [doi]
[168]Immunogenicity of Protein-N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates in A/J and B10 Mice. P A Flanagan, R Duncan, B R̆íhová, V Šubr, J Kopeček. J Bioact Compat Polym. 5 (1990): 151-166. [doi]
[167]The pharmacokinetics of polymer-bound adriamycin. L W Seymour, K Ulbrich, J Strohalm, J Kopeček, R Duncan. Biochem. Pharmacol.. 39 (1990): 1125-1131. [doi]
[166]The potential of water-soluble polymeric carriers in targeted and site-specific drug delivery. J Kopeček. J Control Release. 11 (1990): 279-290. [doi]
[165]Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model. J Cassidy, R Duncan, G J Morrison, J Strohalm, D Plocová, J Kopeček, S B Kaye. Biochem. Pharmacol.. 38 (1989): 875-879.
[164]Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates. Pauline A Flanagan, Pavla Kopec\textbackslashv ková, Jindr\textbackslashv ich Kopec\textbackslashv ek, R Duncan. Biochim. Biophys. Acta. 993 (1989): 83-91. [doi]
[163]Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: Preliminary application to an anticancer agent, daunomycin. Kathryn B O’Hare, I C Hume, Lynne Scarlett, V Chytrý, P Kopečková, J Kopeček, R Duncan. Hepatology. 10 (1989): 207-214. [doi]
[162]Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants. Jin Ho Lee, J Kopeček, J D Andrade. J. Biomed. Mater. Res.. 23 (1989): 351-368. [doi]
[161]Investigation of the aminolysis of p-nitrophenyl esters of (meth)acryloylaminophenoxyacetic acids and their copolymers with N-(2-hydroxypropyl)methacrylamide by 6-aminopenicillanic acid. M V Solovskij, K Ulbrich, O V Nazarova, N V Zubko, E F Panarin, J Kopeček. Die Makromolekulare Chemie. 190 (1989): 2245-2254. [doi]
[160]Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycinImmunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro. B R̆íhová, M Bilej, V Vĕtvicka, K Ulbrich, J Strohalm, J Kopeček, R Duncan. Biomaterials. 10 (1989): 335-342. [doi]
[159]Action of polymeric prodrugs based on N-(2-hydroxypropyl)-methacrylamide copolymers. II. Body distribution and T-cell accumulation of free and polymer-bound [125i]daunomycin. B R̆íhová, K Veres, L Fornusek, K Ulbrich, J Strohalm, V Vĕtvicka, M Bilej, J Kopeček. J Control Release. 10 (1989): 37-49. [doi]
[158]Action of polymeric prodrugs based on N-(2 hydroxypropylmethacrylamide) copolymers I. Suppression of the antibody response and proliferation of mouse splenocytes in vitro. B R̆íhová, V Vĕtvicka, J Strohalm, K Ulbrich, J Kopeček. J Control Release. 9 (1989): 21-32. [doi]
[157]Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo. R Duncan, I C Hume, P Kopečková, K Ulbrich, J Strohalm, J Kopeček. J Control Release. 10 (1989): 51-64. [doi]
[156]Osmotic opening of the blood-brain barrier permeability to N-(2-hydroxypropyl)methacrylamide copolymers. Effect of polymer MW charge and hydrophobicity. B K Armstrong, Q Smith, S I Rapoport, J Strohalm, J Kopeček, R Duncan. J Control Release. 10 (1989): 27-36. [doi]
[155]Optically controlled ligand delivery, 1. Synthesis of water-soluble copolymers containing photocleavable bonds. H.-R. Yen, J Kopeček, J D Andrade. Die Makromolekulare Chemie. 190 (1989): 69-82. [doi]
[154]Soluble Synthetic Polymers for Targeting and Controlled Release of Anticancer Agents, Particularly Anthracycline Antibiotics. R Duncan, L W Seymour, K Ulbrich, J Kopeček. J Bioact Compat Polym. 3 (1988): 4-15. [doi]
[153]Targetable Photoactivatable Drugs. 1. Synthesis Of Water-Soluble Galactosamine Containing Polymeric Carriers Of Chlorin e6 And Their Photodynamic Effect On Plc Cells In Vitro. N L Krinick, B R̆íhová, K Ulbrich, J D Andrade, J Kopeček. Proc. SPIE. 997 (1988): 70-83. [doi]
[152]Cleavage of oligopeptide side-chains in N-(2-hydroxypropyl)meth-acrylamide copolymers by mixtures of lysosomal enzymes. V Šubr, J Kopeček, J Pohl, M Baudyš, V Kostka. J Control Release. 8 (1988): 133-140. [doi]
[151]On-line sensors for coagulation proteins: concept and progress report. J D Andrade, J Herron, J N Lin, H.-R. Yen, J Kopeček, P Kopečková. Biomaterials. 9 (1988): 76-79. [doi]
[150]Development of Tailor-Made Polymeric Prodrugs for Systemic and Oral Delivery. J Kopeček. J Bioact Compat Polym. 3 (1988): 16-26. [doi]
[149]Soluble N-(2-hydroxypropyl) methacrylamide copolymers as a potential oral, controlled-release, drug delivery system. I. Bioadhesion to the rat intestine in vitro. J F Bridges, J F Woodley, R Duncan, J Kopeček. Int J Pharm. 44 (1988): 213-224. [doi]
[148]Antibody-directed affinity therapy applied to the immune system: In vivo effectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody. B R̆íhová, P Kopečková, J Strohalm, P Rossmann, V Vĕtvicka, J Kopeček. Clin. Immunol. Immunopathol.. 46 (1988): 100-114. [doi]
[147]Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.. R Duncan, P Kopečková, J Strohalm, I C Hume, J B Lloyd, J Kopeček. Br. J. Cancer. 57 (1988): 147.
[146]The role of water at the permeation of non-electrolytes through hydrophilic membranes. H Braselmann, D Kirstein, J Vacík, J Kopeček. Acta Polymerica. 38 (1987): 196-199. [doi]
[145]Targetable polymeric prodrugs. J Kopeček, R Duncan. J Control Release. 6 (1987): 315-328. [doi]
[144]Solution properties of drug carriers based on poly[N-(2-hydroxypropyl)methacrylamide] containing biodegradable bonds. K Ulbrich, Č Koňák, Z Tuzar, J Kopeček. Die Makromolekulare Chemie. 188 (1987): 1261-1272. [doi]
[143]Copolymers of 6-O-Methacryloyl-D-Galactose and N-(2-Hydroxypropyl)methacrylamide: Targeting to Liver after Intravenous Administration to Rats. V Chytrý, J Kopeček, E Leibnitz, K B O’Hare, L Scarlett, R Duncan. New Polymeric Mat.. 1 (1987): 21-28.
[142]Polymer-bound derivatives of sarcolysin and their antitumour activity against mouse and human leukaemia in vitro. K Ulbrich, E I Zacharieva, J Kopeček, I C Hume, R Duncan. Die Makromolekulare Chemie. 188 (1987): 2497-2509. [doi]
[141]Potential of Sugar Residues Attached to N-(2- Hydroxypropyl)methacryl amide Copolymers as Targeting Groups for the Selective Delivery of Drugs. L W Seymour, R Duncan, P Kopečková, J Kopeček. J Bioact Compat Polym. 2 (1987): 97-119. [doi]
[140]Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats. L W Seymour, R Duncan, J Strohalm, J Kopeček. J. Biomed. Mater. Res.. 21 (1987): 1341-1358. [doi]
[139]Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery. L W Seymour, R Duncan, P Kopečková, J Kopeček. Cancer Treat. Rev.. 14 (1987): 319-327. [doi]
[138]Poly[N-(2-Hydroxypropyl)methacrylamide] Macromolecules as Drug Carrier Systems. V Šubr, J Kopeček, R Duncan. Polymers in Controlled Drug Delivery. Eds. L Illum, S S Davis. (1987): 152-170.
[137]Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro. R Duncan, P Kopeckova-Rejmanova, J Strohalm, I C Hume, H C Cable, J Pohl, J B Lloyd, J Kopeček. Br. J. Cancer. 55 (1987): 165-174. [doi]
[136]Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers: 3. Targeting by incorporation of galactosamine residues. Effect of route of administration. S A Cartlidge, R Duncan, J B Lloyd, P Kopeckova-Rejmanova, J Kopeček. J Control Release. 4 (1987): 265-278. [doi]
[135]Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers: 2. Effect of molecular weight on blood clearance and body distribution in the rat after intravenous administration. Distribution of unfractionated copolymer after intraperitoneal, subcutaneous or oral administration. S A Cartlidge, R Duncan, J B Lloyd, P Kopeckova-Rejmanova, J Kopeček. J Control Release. 4 (1987): 253-264. [doi]
[134]Separation of human lymphoid cells by affinity chromatography and cell surface labelling by hydroxyethyl methacrylate particles using monoclonal antibodies. H Tlaskalová Hogenová, J Coupek, A Frydrychova, V Vĕtvicka, J Kopeček, M Pospíšil, H Fiebig, L Prokesova, P Mancal. J. Chromatogr.. 376 (1986): 401-408. [doi]
[133]Pinocytic capture and exocytosis of rat immunoglobulin IgG-N-(2-hydroxy-propyl)methacrylamide copolymer conjugates by rat visceral yolk sacs culturedin vitro. R Duncan, H C Cable, J Strohalm, J Kopeček. Biosci. Rep.. 6 (1986): 869-877.
[132]Effect of a synthetic poly N-(2-hydroxypropyl)methacrylamide (Duxon) on haemopoiesis and graft-versus-host reaction. E Paluska, A Hruba, O Sterba, J Kopeček. Folia Biol. (Praha). 32 (1986): 91-102.
[131]Degradation of Oligopeptide Sequences Connecting Poly[N-(2- hydroxypropyl)methacrylamide] Chains by Lysosomal Cysteine Proteinases. V Šubr, J Kopeček, R Duncan. J Bioact Compat Polym. 1 (1986): 133-146. [doi]
[130]The Activity of Complement in the Presence of N-(2-hydroxypropyl)methacrylamide Copolymers. J Šimečková, B R̆íhová, D Plocová, J Kopeček. J Bioact Compat Polym. 1 (1986): 20-31. [doi]
[129]Synthetic polymers as carriers for chemotherapeutic agents. J B Lloyd, R Duncan, J Kopeček. Biochem. Soc. Trans.. 14 (1986): 391-392.
[128]Co-expression of different types of Fc receptors on murine peritoneal macrophages. Václav Větvička, Lubor Forn\textbackslashr u, Paul W Kincade, J Kopeček. Eur. J. Immunol.. 16 (1986): 901-905. [doi]
[127]Interaction of a Cationic N-(2-hydroxypropyl)methacrylamide Copolymer with Rat Visceral Yolk Sacs Cultured in vitro and Rat Liver in vivo. L A Mccormick, L C W Seymour, R Duncan, J Kopeček. J Bioact Compat Polym. 1 (1986): 4-19. [doi]
[126]Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers. B Rihova, J Kopeček, P Kopeckova-Rejmanova, J Strohalm, D Plocová, H Semoradova. J. Chromatogr.. 376 (1986): 221-233. [doi]
[125]Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats. R Duncan, L C W Seymour, L Scarlett, J B Lloyd, P Rejmanová, J Kopeček. Biochim. Biophys. Acta. 880 (1986): 62-71. [doi]
[124]A lysosomotropic polymeric inhibitor of cysteine proteinases. V Šubr, R Duncan, K Hanada, H C Cable, J Kopeček. J Control Release. 4 (1986): 63-68. [doi]
[123]Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers: Pinocytosis by rat visceral yolk sacs and rat intestine cultured in vitro. Effect of molecular weight on uptake and intracellular degradation. S A Cartlidge, R Duncan, J B Lloyd, P Rejmanová, J Kopeček. J Control Release. 3 (1986): 55-66. [doi]
[122]Poly(ethylene glycol)s containing enzymatically degradable bonds. K Ulbrich, J Strohalm, J Kopeček. Die Makromolekulare Chemie. 187 (1986): 1131-1144. [doi]
[121]In vivo and in vitro immunogenicity of water-soluble haptenated copolymers for mouse and human lymphocytes. H Tlaskalová Hogenová, J Kopeček, K Ulbrich, F Rypáček, M Pospíšil. Die Makromolekulare Chemie. 9S (1985): 137-143. [doi]
[120]Biological properties of targetable poly[N-(2-hydroxypropyl)-methacrylamide]-antibody conjugates. B R̆íhová, J Kopeček. J Control Release. 2 (1985): 289-310. [doi]
[119]Immunogenicity of N-(2-hydroxypropyl) methacrylamide copolymers. B R̆íhová, J Kopeček, K Ulbrich, V Chytrý. Die Makromolekulare Chemie. 9S (1985): 13-24. [doi]
[118]Polymers with Controlled Biodegradability as Carriers of Biologically Active Compounds (in Russian). J Kopeček. Zhur. Khim. Obsh.. 30 (1985): 372-378.
[117]Hydrophilic polymeric microspheres : Their use in immunological methods. L Fornusek, V Vĕtvicka, J Zídková, J Kopeček. Die Makromolekulare Chemie. 9S (1985): 125-127. [doi]
[116]Controlled Release of Drug Model from N-(2-Hydroxypropyl)methacrylamide Copolymers. J Kopeček, P Rejmanová, R Duncan, J B Lloyd. Ann NY Acad Sci. 446 (1985): 93-104.
[115]Targeting and Lysosomal Handling of Polymethacrylamide – Oligopeptide Conjugates. J B Lloyd, R Duncan, J Kopeček, P Rejmanová. Receptor-Mediated Targeting of Drugs. Eds. G Gregoriadis, G Poste, J Senior, A Trouet. (1985): 417-425.
[114]Methods of targeting N-(2-hydroxypropyl) methacrylamide copolymers to particular cell types. R Duncan, J B Lloyd, P Rejmanová, J Kopeček. Die Makromolekulare Chemie. 9 (1985): 3-12. [doi]
[113]Preparation of polymer-modified enzymes of prolonged circulation times. Poly[N-(2-hydroxypropyl) methacrylamide]-bound acetylcholinesterase. A Lääne, Aavo Aaviksaar, M Haga, V Chytrý, J Kopeček. Die Makromolekulare Chemie. 9 (1985): 35-42. [doi]
[112]Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers. P Rejmanová, J Kopeček, R Duncan, J B Lloyd. Biomaterials. 6 (1985): 45-48. [doi]
[111]Influence of medium and matrix composition on diffusivities in charged membranes. D Kirstein, H Braselmann, J Vacík, J Kopeček. Biotechnol. Bioeng.. 27 (1985): 1382-1384. [doi]
[110]Properties of macrophages from low- and high-responder strains of mice. I. Effect of antigenic stimulation. V Vĕtvicka, L Fornusek, B R̆íhová, J Kopeček. Folia Biol. (Praha). 31 (1985): 20-33.
[109]Macrophages of athymic nude mice: Fc receptors, C receptors, phagocytic and pinocytic activities.. V Vĕtvicka, L Fornusek, M Holub, J Zídková, J Kopeček. Eur J Cell Biol. 35 (1984): 35-40.
[108]Targeting of soluble cross-linked N-(2-hydroxypropyl)methacrylamide copolymers in vivo. A potential drug delivery system. S A Cartlidge, P Rejmanová, R Duncan, J Kopeček, J B Lloyd. Biochem. Soc. Trans.. 12 (1984): 1064-1065.
[107]Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers. R Duncan, H C Cable, P Rejmanová, J Kopeček, J B Lloyd. Biochim. Biophys. Acta. 799 (1984): 1-8.
[106]Effect of the chemical structure of N-(2-hydroxypropyl)methacrylamide copolymers on their ability to induce antibody formation in inbred strains of mice. B R̆íhová, J Kopeček, K Ulbrich, M Pospíšil, P Mancal. Biomaterials. 5 (1984): 143-148.
[105]Polymers containing enzymatically degradable bonds, 9. Chymotrypsm catalyzed hydrolysis of a p-nitroanilide drug model, p bound via oligopeptides onto poly(vinylpyrrolidone-co-maleic anhydride). J Pató, M Azori, K Ulbrich, J Kopeček. Die Makromolekulare Chemie. 185 (1984): 231-237. [doi]
[104]Synthetic polymers as targetable carries for drugs. J B Lloyd, R Duncan, J Kopeček. Pure Appl. Chem.. 56 (1984): 1301-1304. [doi]
[103]Drug targeting to lysosomes. R Duncan, J Kopeček, J B Lloyd. Biochem. Soc. Trans.. 12 (1984): 1064-1065.
[102]Controlled biodegradability of polymers–a key to drug delivery systems. J Kopeček. Biomaterials. 5 (1984): 19-25.
[101]Synthesis of Tailor-Made Soluble Polymeric Drug Carriers. J Kopeček. Recent Advances in Drug Delivery Systems. Ed. S-W Kim. (1984): 41-62.
[100]Soluble synthetic polymers as potential drug carriers. R Duncan, J Kopeček. Adv. Polym. Sci.. 57 (1984): 51-101. [doi]
[99]An advantageous method for detection of Fc-receptors and for studying Fc-receptor-mediated phagocytosis. L Fornusek, J Kopeček, V Vĕtvicka. Immunol Lett.. 7 (1983): 29-33.
[98]Phagocytosis of 2-hydroxyethylmethacrylate copolymer particles by different types of macrophages. V Vĕtvicka, L Fornusek, J Kopeček, D Prikrylova. Folia Biol. (Praha). 29 (1983): 424-428.
[97]Polymers containing enzymatically degradable bonds, 8. Degradation of oligopeptide sequences in N-(2-hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B. P Rejmanová, J Kopeček, J Pohl, M Baudyš, V Kostka. Die Makromolekulare Chemie. 184 (1983): 2009-2020. [doi]
[96]Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues. R Duncan, J Kopeček, P Rejmanová, J B Lloyd. Biochim. Biophys. Acta. 755 (1983): 518-521.
[95]Development of N-(2-Hydroxypropyl)methacrylamide Copolymers as Carriers of Therapeutic Agents. R Duncan, J Kopeček, J B Lloyd. Polymers in Medicine Biomedical and Pharmacological Applications. Eds. E Chiellini, P Giusti. (1983): 97-113.
[94]Biodegradation of biomedical polymers. J Kopeček, K Ulbrich. Prog Polym Sci. 9 (1983): 1-58. [doi]
[93]Enzymatically Degradable Bonds in Synthetic Polymers. J Kopeček, P Rejmanová. Controlled Drug Delivery. Ed. S D Bruck. (1983): 81-124.
[92]Activation of poly[N-(2-hydroxypropyl)methacrylamide] for the binding of bioactive molecules, 2. Activation with cyanogen bromide. V Chytrý, J Kopeček. Die Makromolekulare Chemie. 184 (1983): 1345-1353. [doi]
[91]Activation of poly[N-(2-hydroxypropyl)methacrylamide] for the binding of bioactive molecules, 1. Activation with 4-nitrophenyl chloroformate. A Lääne, M Haga, Aavo Aaviksaar, V Chytrý, J Kopeček. Die Makromolekulare Chemie. 184 (1983): 1339-1344. [doi]
[90]Immunogenicity of N-(2-hydroxypropyl)-methacrylamide copolymers–potential hapten or drug carriers. B R̆íhová, K Ulbrich, J Kopeček, P Mancal. Folia Microbiol. (Praha). 28 (1983): 217-227.
[89]Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side-chains in poly[N-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes. R Duncan, H C Cable, J B Lloyd, P Rejmanová, J Kopeček. Die Makromolekulare Chemie. 184 (1983): 1997-2008. [doi]
[88]Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity. M V Solovskij, K Ulbrich, J Kopeček. Biomaterials. 4 (1983): 44-48.
[87]Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases. R Duncan, H C Cable, J B Lloyd, P Rejmanová, J Kopeček. Biosci. Rep.. 2 (1982): 1041-1046.
[86]Phagocytosis of human blood leukocytes: a simple micromethod. V Vĕtvicka, L Fornusek, J Kopeček, J Kaminkova, L Kasparek, M Vranova. Immunol Lett.. 5 (1982): 97-100.
[85]Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin. K Ulbrich, J Strohalm, J Kopeček. Biomaterials. 3 (1982): 150-154.
[84]A convenient model system for the study of the influence of water-soluble polymer carrier on the interaction between proteins. V Chytrý, J Kopeček, P Sikk, R Sinijärv, Aavo Aaviksaar. Makromol. Chem. Rapid Commun.. 3 (1982): 11-15. [doi]
[83]Biodegradation of Polymers for Biomedical Use. J Kopeček. IUPAC Macromolecules. Eds. H Benoit, P Rempp. (1982): 305-320.
[82]Pinocytic uptake and intracellular degradation of N-(2-hydroxypropyl)methacrylamide copolymers. A potential drug delivery system. R Duncan, P Rejmanová, J Kopeček, J B Lloyd. Biochim. Biophys. Acta. 678 (1981): 143-150.
[81]Differences in phagocytic activity of methacrylate copolymer particles in normal and stimulated macrophages. L Fornusek, V Vĕtvicka, J Kopeček. Experientia. 37 (1981): 418-420.
[80]The photoelastic behaviour of dry and swollen networks of poly (N,N-diethylacrylamide) and of its copolymer with N-tert.butylacrylamide. J Hrouz, M Ilavský, K Ulbrich, J Kopeček. Eur Polym J. 17 (1981): 361-366. [doi]
[79]Polymers containing enzymatically degradable bonds, 4. Preliminary experiments in vivo. J Kopeček, I Cífková, P Rejmanová, J Strohalm, B Obereigner, K Ulbrich. Die Makromolekulare Chemie. 182 (1981): 2941-2949. [doi]
[78]Polymers containing enzymatically degradable bonds, 3. Poly[N-(2-hydroxypropyl)methacrylamide] chains connected by oligopeptide sequences cleavable by trypsin. K Ulbrich, J Strohalm, J Kopeček. Die Makromolekulare Chemie. 182 (1981): 1917-1928. [doi]
[77]Polymers containing enzymatically degradable bonds, 2. Poly[N-(2-hydroxypropyl)methacrylamide] chains connected by oligopeptide sequences cleavable by chymotrypsin. P Rejmanová, B Obereigner, J Kopeček. Die Makromolekulare Chemie. 182 (1981): 1899-1915. [doi]
[76]Polymers containing enzymatically degradable bonds, 1. Chymotrypsin catalyzed hydrolysis of p-nitroanilides of phenylalanine and tyrosine attached to side-chains of copolymers of N-(2-hydroxypropyl)methacrylamide. J Kopeček, P Rejmanová, V Chytrý. Die Makromolekulare Chemie. 182 (1981): 799-809. [doi]
[75]Hydrophilic Biomedical Polymers (in Bulgarian). J Kopeček. Chimija i Industrija. (1981): 224-227.
[74]Soluble Polymers in Medicine. J Kopeček. Systemic Aspects of Biocompatibility. Ed. D F Williams. (1981): 159-180.
[73]Covalent attachment of chymotrypsin to poly[N-(2-hydroxypropyl)methacrylamide]. A Lääne, V Chytrý, M Haga, P Sikk, Aavo Aaviksaar, J Kopeček. CCCC. 46 (1981): 1466-1473. [doi]
[72]New types of synthetic infusion solutions. The effect of Duxon on cell proliferation in vitro. J Cinatl, O Sterba, E Paluska, V Polednova, J Kopeček. Ceskoslovenska farmacie. 29 (1980): 134-138.
[71]Duxon–a new Czechoslovak–made infusion solution–an experimental contribution to biological evaluation. O Sterba, Z Uhlirova, R Petz, L Viktora, A Jirasek, J Kopeček. Cas. Lek. Cesk.. 119 (1980): 994-997.
[70]Degradation of side chains of N-(2-hydroxypropyl) methacrylamide copolymers by lysosomal enzymes. R Duncan, J B Lloyd, J Kopeček. Biochem Biophys Res Commun. 94 (1980): 284-290.
[69]Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain. K Ulbrich, E I Zacharieva, B Obereigner, J Kopeček. Biomaterials. 1 (1980): 199-204.
[68]Immunosuppressive effects of a synthetic polymer poly N-(2-hydroxypropyl)methacrylamide (Duxon). E Paluska, J Cinatl, L Korcakova, O Sterba, J Kopeček, A Hruba, J Nezvalova, R Stanek. Folia Biol. (Praha). 26 (1980): 304-311.
[67]Strong-acid membranes with enhanced hydrophilicity. V K\textbackslashr udela, J Vacík, J Kopeček. J Memb Sci. 6 (1980): 123-131. [doi]
[66]Regulation of transport in artificial membranes by environmental hydrogen-ion concentration. H Braselmann, J Vacík, J Kopeček, D Kirstein. Eur Polym J. 16 (1980): 431-435. [doi]
[65]Comparison of the functional activity of normal and stimulated peritoneal exudate cells in suspension and after adherence to the substrate. V Vĕtvicka, V Viklicky, L Jaroskova, J Kopeček. Folia Biol. (Praha). 25 (1979): 403-404.
[64]Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide and (2-hydroxyethyl) methacrylate. Study of sorption properties. J Vacík, L K Shataeva, G V Samsonov, Jaroslav Kálal, J Kopeček. CCCC. 44 (1979): 1931-1941. [doi]
[63]Porous copolymers of methacrylic acid with N-(2-hydroxypropyl) methacrylamide and (2-hydroxyethyl) methacrylate. Preparation, swelling and morphology. J Vacík, Z Pelzbauer, Nadezhda N Kuznetsova, K P Papukova, L K Shataeva, G V Samsonov, Jaroslav Kálal, J Kopeček. CCCC. 44 (1979): 1925-1930. [doi]
[62]Permeability of heterogeneous membranes based on methacrylic acid. L K Shatayeva, G V Samsonov, J Vacík, J Kopeček, J Kalal. J Appl Polym Sci. 23 (1979): 2245-2251. [doi]
[61]Reactive copolymers of N-(2-hydroxypropyl) methacrylamide with N-methacryloylated derivatives of l-leucine and l-phenylalanine. II. Reaction with the polymeric amine and stability of cross-links towards chymotrypsin in vitro. J Kopeček, P Rejmanová. J. Polym. Sci., Polym. Symp.. 66 (1979): 15-32. [doi]
[60]Cross-linked copolymers of N,N-diethylacrylamide with improved mechanical properties. K Ulbrich, J Kopeček. J. Polym. Sci., Polym. Symp.. 66 (1979): 209-219. [doi]
[59]Preparation of polymerizable derivatives of N-(4-aminobenzenesulfonyl)-n´-butylurea. B Obereigner, M Burešová, A Vrána, J Kopeček. J. Polym. Sci., Polym. Symp.. 66 (1979): 41-52. [doi]
[58]Deformational, swelling, and potentiometric behavior of ionized gels of 2-hydroxyethyl methacrylate–methacrylic acid copolymers. M Ilavský, K Dušek, J Vacík, J Kopeček. J Appl Polym Sci. 23 (1979): 2073-2082. [doi]
[57]Supermolecular Structure of Hydrophilic Polymers Based on Poly(Glycol Methacrylates) Contacted with the Organism’s Tissue (in Russian). J Kalal, L Šprincl, J Kopeček, T E Lipatova, E V Lebedev, N I Dovgopol. Vysokomol. Soed.. 20 (1978): 751-755.
[56]Permeability of hydrophilic membranes based on N-substituted (meth)acrylamides. J Vacík, K Ulbrich, J Exner, J Kopeček. CCCC. 43 (1978): 1221-1226. [doi]
[55]Poly[N-(2-hydroxypropyl)methacrylamide]. IV. Heterogeneous polymerization. J Strohalm, J Kopeček. Die Angewandte Makromolekulare Chemie. 70 (1978): 109-118. [doi]
[54]Synthetic Polymers in Chemotherapy: General Problems. J Kalal, J Drobník, J Kopeček, J Exner. Polymeric Drugs. Eds. L G Donaruma, O Vogl. Academic Press (1978): 131-159.
[53]Water Soluble Polymers for Medicine. Jaroslav Kálal, J Drobník, J Kopeček, J Exner. British Polymer Journal. 10 (1978): 111-114. [doi]
[52]Preparation and properties of poly-(N-butylmethacrylamide) networks. K Ulbrich, K Dušek, M Ilavský, J Kopeček. Eur Polym J. 14 (1978): 45-49. [doi]
[51]Synthesis and activity of a polymer which contains insulin covalently bound on a copolymer of N-(2-hydroxypropyl)methacrylamide and N-methacryloyldiglycyl p-nitrophenyl ester. V Chytrý, A Vrána, J Kopeček. Die Makromolekulare Chemie. 179 (1978): 329-336. [doi]
[50]Preparation and properties of poly(2,4-pentadiene-1-ol). K Ulbrich, M Ilavský, B Obereigner, J Kopeček. Die Angewandte Makromolekulare Chemie. 67 (1978): 137-149. [doi]
[49]pH-dependent electrochemical behaviour of hydrophilic ampholytic membranes. V K\textbackslashr udela, J Vacík, J Kopeček. Eur Polym J. 13 (1977): 811-813. [doi]
[48]Biological Effects of 2,4-Pentadiene-1-ol. O Benesova, L Šprincl, K Ulbrich, B Obereigner, J Drobník, J Kalal, J Kopeček. Chem. Biol. Interact.. 18 (1977): 111-118. [doi]
[47]Reactive copolymers of N-(2-hydroxypropyl)methacrylamide with N-methacryloylated derivatives of L-leucine and L-phenylalanine, 1. Preparation, characterization, and reactions with diamines. J Kopeček. Die Makromolekulare Chemie. 178 (1977): 2169-2183. [doi]
[46]Permeability of metabolites through hydrophilic membranes. J Vacík, M Czaková, J Exner, J Kalal, J Kopeček. CCCC. 42 (1977): 2786-2790. [doi]
[45]Polymerization kinetics of N,N-diethylacrylamide. K Ulbrich, L Čech, J Kalal, J Kopeček. CCCC. 42 (1977): 2666-2671. [doi]
[44]Preparation and properties of poly(N-ethylmethacrylamide) networks. K Ulbrich, M Ilavský, K Dušek, J Kopeček. Eur Polym J. 13 (1977): 579-585. [doi]
[43]Soluble biomedical polymers. J Kopeček. Polim Med. 7 (1977): 191-221.
[42]Aminolyses of monomeric and polymeric 4-nitrophenyl esters of N-methacryloylamino acids. P Rejmanová, J Labský, J Kopeček. Die Makromolekulare Chemie. 178 (1977): 2159-2168. [doi]
[41]New types of synthetic infusion solutions. III. Elimination and retention of poly-[N-(2-hydroxypropyl)methacrylamide] in a test organism. L Šprincl, J Exner, O Sterba, J Kopeček. J. Biomed. Mater. Res.. 10 (1976): 953-963. [doi]
[40]A simple test for immunogenicity of colloidal infusion solutions- the draining lymph node activation.. L Korcakova, E Paluska, V Haskova, J Kopeček. Z Immunitatsforsch Exp Klin Immunol. 151 (1976): 219-223.
[39]Mucopolysaccharide complexes in the fibrous tissue surrounding hydrophilic polymers in subcutaneous implantation. L Šprincl, T L Terescenko, J Kalal, T E Lipatova, J Kopeček, G A Pchakadze. Polim Med. 6 (1976): 185-190.
[38]Comparative Characteristics of Polyurethanes and Hydrophilic Polymers Based on Poly(Glycol Methacrylates) Used as Alloplastics (in Ukrainian). T E Lipatova, G A Pchakadze, T L Terescenko, J Kalal, L Šprincl, J Kopeček. Izv. Ukr. Acad. Sci.. 3 (1976): 33-45.
[37]Enzymatic cleavage of side chains of synthetic water-soluble polymers. J Drobník, J Kopeček, J Labský, P Rejmanová, J Exner, V Saudek, J Kalal. Die Makromolekulare Chemie. 177 (1976): 2833-2848. [doi]
[36]Polymerization kinetics of N-ethylacrylamide. K Ulbrich, J Kopeček. CCCC. 41 (1976): 61-66. [doi]
[35]Radical polymerization of n-substituted methacrylamides. K Ulbrich, J Kopeček. Eur Polym J. 12 (1976): 183-187. [doi]
[34]New Types of Polyurethane Tissue Adhesives and Their Application in Surgery (In Czech). T E Lipatova, G A Pchakadze, T L Terescenko, L Šprincl, J Kalal, J Kopeček. Voj. zdrav. listy. 45 (1976): 25-29.
[33]Copolymerization of N-ethylacrylamide with N-monosubstituted methacrylamides. J Strohalm, K Ulbrich, J Exner, J Kopeček. Die Angewandte Makromolekulare Chemie. 49 (1976): 83-92. [doi]
[32]Mechanical Responses of 2-Hydroxyethyl Methacrylate-Methacrylonitrile and 2-Hydroxyethyl Methacrylate-Acrylonitrile Copolymer Networks. J Janáĉek, J Kolarik, J Vacík, J Kopeček. Int J Polym Mater. 5 (1976): 59-70. [doi]
[31]Relaxation Behavior of Poly(N-monosubstituted Methacrylamides). J Kolarik, J Kopeček, J Vacík, J Janáĉek. Int J Polym Mater. 5 (1976): 89-97. [doi]
[30]New types of synthetic infusion solutions. Basic biological properties of poly(N-(2-hydroxypropyl) methacrylamide). O Sterba, E Paluska, O Jozova, J Spunda, J Nezvalova, L Šprincl, J Kopeček, J Cinatl. Cas. Lek. Cesk.. 114 (1975): 1268-1270.
[29]Specific resistances of hydrophilic membranes containing ionogenic groups. J Vacík, J Kopeček. J Appl Polym Sci. 19 (1975): 3029-3044. [doi]
[28]Adjusting of Thin Layer Resistors with an Anodizing Electrode (in Czech). S Luby, E Sumbalova, J Kopeček. Elektrotechnicky casopis. 26 (1975): 297-304.
[27]Concentration potentials of hydrophilic membranes containing ionogenic groups. J Vacík, V K\textbackslashr udela, J Kopeček. Eur Polym J. 11 (1975): 331-335. [doi]
[26]Long-term experience with poly(glycol monomethacrylate) gel in plastic operations of the nose. Z Voldrich, Z Tomanek, J Vacík, J Kopeček. J. Biomed. Mater. Res.. 9 (1975): 675-685. [doi]
[25]Relaxation Behaviour of Poly(2-Hydroxyethyl Acrylate) and of Its Copolymers with 2-Hydroxyethyl Methacrylate. J Kolarik, J Vacík, J Kopeček. Int J Polym Mater. 3 (1975): 259-267. [doi]
[24]Evaluation of Biological Properties of Polymeric Materials (in Czech). L Šprincl, J Kalal, J Kopeček. Lekar a technika. 6 (1974): 110-114.
[23]Poly[N-(2-hydroxypropyl)methacrylamide]—iii Crosslinking copolymerization. J Kopeček, H Baẑilová. Eur Polym J. 10 (1974): 465-470. [doi]
[22]Poly[N-(2-hydroxypropyl)methacrylamide]—ii Hydrodynamic properties of dilute solutions. M Bohdanecky, H Baẑilová, J Kopeček. Eur Polym J. 10 (1974): 405-410. [doi]
[21]Relationship between the structure and biocompatibility of hydrophilic gels. J Kopeček, L Šprincl. Polim Med. 4 (1974): 109-117.
[20]Biocompatibility of poly (2,4-pentadiene-1-ol). K Ulbrich, L Šprincl, J Kopeček. J. Biomed. Mater. Res.. 8 (1974): 155-161. [doi]
[19]Poly[N-(2-hydroxypropyl)methacrylamide]—I. Radical polymerization and copolymerization. J Kopeček, H Baẑilová. Eur Polym J. 9 (1973): 7-14. [doi]
[18]Effect of the structure of poly(glycol monomethacrylate) gel on the calcification of implants. L Sprinel, J Kopeček, D Lím. Calcif Tissue Res. 13 (1973): 63-72.
[17]New types of synthetic infusion solutions. I. Investigation of the effect of solutions of some hydrophilic polymers on blood. J Kopeček, L Šprincl, D Lím. J. Biomed. Mater. Res.. 7 (1973): 179-191. [doi]
[16]Effect of the hydrophilic character of the polymeric backbone on membrane permeability. J Kopeček, J Vacík. CCCC. 38 (1973): 854-860. [doi]
[15]Biological tolerance of poly(N-substituted acrylamides). J Kopeček, L Šprincl, H Baẑilová, J Vacík. J. Biomed. Mater. Res.. 7 (1973): 111-121. [doi]
[14]Biological tolerance of ionogenic hydrophilic gels. L Šprincl, J Vacík, J Kopeček. J. Biomed. Mater. Res.. 7 (1973): 123-136. [doi]
[13]Mechanism of three-dimensional polymerization of glycol methacrylates. IV. The system triglycol monomethacrylate-glycol dimethacrylates-water. J Kopeček, D Lím. CCCC. 36 (1971): 3394-3398. [doi]
[12]Mechanism of three-dimensional polymerization of glycol methacrylates. III. Contribution to the polymerization kinetics of the system diglycol monomethacrylate-glycol dimethacrylates-water. J Kopeček, D Lím. CCCC. 36 (1971): 2703-2707. [doi]
[11]Effect of porosity of heterogeneous poly(glycol monomethacrylate) gels on the healing-in of test implants. L Šprincl, J Kopeček, D Lím. J. Biomed. Mater. Res.. 5 (1971): 447-458. [doi]
[10]Permeability of membranes containing ionogenic groups. J Kopeček, J Vacík, D Lím. J Polym Sci A1. 9 (1971): 2801-2815. [doi]
[9]Mechanism of the three-dimensional polymerization of glycol methacrylates. II. The system glycol monomethacrylate–glycol dimethacrylates–solvents. J Kopeček, D Lím. J Polym Sci A1. 9 (1971): 147-154. [doi]
[8]Biological tolerance of poly(N-substituted methacrylamides). L Šprincl, J Kopeček, J Vacík, D Lím. J. Biomed. Mater. Res.. 5 (1971): 197-205. [doi]
[7]Performance of Porous Cellulose Acetate Membranes for the Reverse Osmosis Separation of Mixtures of Organic Liquids. J Kopeček, S Sourirajan. Ind. Eng. Chem. Proc. Des. Dev.. 9 (1970): 5-12. [doi]
[6]Reverse Osmosis. J Kopeček. Chem. Listy.. 63 (1969): 1338-1353.
[5]Equisorptic compositions in reverse osmosis. J Kopeček, S Sourirajan. Can J Chem. 47 (1969): 3467-3469.
[4]Performance of Porous Cellulose Acetate Membranes in Some Reverse Osmosis Experiments. J Kopeček, S Sourirajan. Ind. Eng. Chem. Prod. Res. Dev.. 8 (1969): 274-279. [doi]
[3]Structure of porous cellulose acetate membranes and a method for improving their performance in reverse osmosis. J Kopeček, S Sourirajan. J Appl Polym Sci. 13 (1969): 637-657. [doi]
[2]Mechanism of three-dimensional polymerization of the system methyl methacrylate–glycol dimethacrylate. I. Determination of the structure of the three-dimensional product. J Jokl, J Kopeček, D Lím. J Polym Sci A1. 6 (1968): 3041-3048. [doi]
[1]Mechanism of Three-Dimensional Polymerization of Glycol Methacrylates. J Kopeček, J Jokl, D Lím. J Polym Sci C. 16 (1968): 3877-3889. [doi]