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June 1, 2025
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Kopecek / Yang Lab – University of Utah

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Department of Molecular Pharmaceutics

Department of Biomedical Engineering

Huntsman Cancer Institue

Biological Chemistry Program

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Recent Publications
    • Two-component T-cell immunotherapy enables antigen pre-targeting to reduce cytokine release without forfeiting efficacy. M.T. Gambles, I. Kendell, J. Li, K. Spaihower, D. Sborov, S. Owen, A. Stark, D. Bearss, J. Yang, J. Kopeček. Nanomedicine: Nanotechnology, Biology and Medicine 67, 102825 (2025) [doi]
    • PD-L1 targeted antibody-polymer-Epirubicin conjugate prolongs survival in a preclinical murine model of advanced ovarian cancer. J. Li, H.A. Al Faruque, S. Li, M. Sima, D. Sborov, S. Hu-Lieskovan, T. Werner, J. Kopeček, J. Yang. J. Controlled Release 382, 113682 (2025) [doi]
    • Blood-brain barrier crossing biopolymer targeting c-Myc and anti-PD-1 activate primary brain lymphoma immunity: artificial intelligence analysis. V.A. Ljubimov, T. Sun, J. Wang, L. Li, P.Z. Wang, A.V. Ljubimov, E. Holler, K.L. Black, J. Kopeček, J.Y. Ljubimova, J. Yang. J. Controlled Release 381, 113611 (2025) [doi]
    • Combination of Multivalent DR5 Receptor Clustering Agonists and Histone Deacetylase Inhibitors for Treatment of Colon Cancer. J. Li, J. Arnold, M. Sima, H. Al Faruque, J. Galang, S. Hu-Lieskovan, J. Kopeček, J. Yang. J. Controlled Release 376, 1014-1024 (2024) [doi]
    • Multiantigen T-Cell Hybridizers: A Two-Component T-Cell-Activating Therapy. M.T. Gambles, S. Li, I. Kendell, J. Li, D. Sborov, P. Shami, J. Yang, J. Kopeček. ACS Nano (2024) [doi]
    • Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics Induce Apoptosis in Chronic Lymphocytic Leukemia Patient Cells by Crosslinking of CD20 and/or CD38 Receptors. J. Li, M.T. Gambles, B. Jones, J.A. Williams, N.J. Camp, P.J. Shami, J. Yang, J. Kopeček. Drug Delivery Translational Res. (2024); [doi].
    • Hydrophilic Biomaterials: From Crosslinked and Self-Assembled Hydrogels to Polymer-Drug Conjugates and Drug-Free Macromolecular Therapeutics. J. Kopeček. Invited “Magnum Opus” manuscript. J. Controlled Release 373, 1-22 (2024); [doi].

 

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